Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- cocaine topical
- Tracleer (bosentan)
Interactions between your drugs
cocaine topical bosentan
Applies to: cocaine topical, Tracleer (bosentan)
MONITOR: Coadministration with bosentan may decrease the plasma concentrations of drugs that are substrates of the CYP450 2C9 and/or 3A4 isoenzymes. The mechanism is accelerated clearance due to induction of those isoenzymes by bosentan.
MANAGEMENT: When drugs that are known substrates of CYP450 2C9 and/or 3A4 are coadministered with bosentan, the possibility of a diminished therapeutic response to those drugs should be considered. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs, particularly those with a narrow therapeutic range, whenever bosentan is added to or withdrawn from therapy.
References (1)
- (2001) "Product Information. Tracleer (bosentan)." Actelion Pharmaceuticals US Inc
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Lidocaine Viscous
Lidocaine Viscous is used for anesthesia, gastrointestinal surgery, gastrointestinal tract ...
Lidoderm
Lidoderm is a lidocaine patch used to relieve nerve pain after shingles by numbing the skin and ...
Taltz
Taltz (ixekizumab) is used to treat plaque psoriasis, psoriatic arthritis, and ankylosing ...
Novocain
Novocain (procaine) is a local anesthetic. Novocain causes loss of feeling (numbness) of skin and ...
Xylocaine Jelly
Xylocaine Jelly is used for anal itching, anesthesia, burns, external, gastrointestinal surgery ...
Pontocaine
Pontocaine is used for allergic urticaria, cold sores, local anesthesia, skin rash, urticaria
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.