Drug Interaction Report

Using donanemab together with blood-thinning or clot-dissolving medications has not been adequately studied. There are some theoretical concerns that combining donanemab and dipyridamole may increase the risk of bleeding in the brain. Talk to your doctor if you have any questions or concerns. Your doctor will do magnetic resonance imaging (MRI) scans before and during your treatment with donanemab as part of monitoring for potential side effects in the brain. You should seek immediate medical attention if you experience signs and symptoms that may suggest more serious treatment complications such as headache, confusion, dizziness, vision changes, nausea, difficulty walking, or seizures. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Caffeine may interfere with the effects of dipyridamole in dilating the arteries. You should avoid caffeine-containing products for at least 24 hours before an imaging procedure involving dipyridamole given by injection. However, no special precaution is necessary if you are taking dipyridamole orally for maintenance.

Ask your doctor before using dipyridamole together with caffeine. Using these medications together can decrease the effects of dipyridamole. It is recommended that caffeine including caffeine be avoided for 12 to 24 hours before dipyridamole administration. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.