Drug Interaction Report

Using donanemab together with blood-thinning or clot-dissolving medications has not been adequately studied. There are some theoretical concerns that combining donanemab and cilostazol may increase the risk of bleeding in the brain. Talk to your doctor if you have any questions or concerns. Your doctor will do magnetic resonance imaging (MRI) scans before and during your treatment with donanemab as part of monitoring for potential side effects in the brain. You should seek immediate medical attention if you experience signs and symptoms that may suggest more serious treatment complications such as headache, confusion, dizziness, vision changes, nausea, difficulty walking, or seizures. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Take cilostazol on an empty stomach 1 hour before or 2 hours after a meal unless otherwise directed by your doctor. Food may reduce the absorption of cilostazol. Taking cilostazol on an empty stomach will make it easier for your body to absorb the medication. If you are receiving therapy with cilostazol you should avoid grapefruits and grapefruit juice. Grapefruit can raise the levels of cilostazol in your body and lead to dangerous side effects. You may experience headache, dizziness, chest pain, feeling short of breath, and swelling of your ankles or feet. Call your doctor at once if you have any of these symptoms.