Drug Interaction Report

Ritonavir may increase the blood levels of the active medication in tisotumab vedotin. This may increase the risk and/or severity of side effects such as nausea; vomiting; diarrhea; loss of appetite; tingling, numbness or burning in the hands and feet; muscle weakness; hair loss; eye disorders (dry eyes, inflammation of the cornea, corneal ulcers, blurred vision, vision loss); bleeding; low red and white blood cell counts; and inflammation of the lungs. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Ritonavir should be taken with food to lessen gastrointestinal side effects. It is important that you take this medication exactly as prescribed by your doctor. Do not change your treatment or stop treatment without first talking to your doctor.

Food significantly increases the absorption of paritaprevir. You should take each dose of paritaprevir with a meal. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication.