Drug Interaction Report

Lapatinib may increase the blood levels and side effects of brincidofovir. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. If you do need to take both medications, you may lessen the risk and severity of interaction by taking lapatinib at least 3 hours after brincidofovir. You may also require more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects such as diarrhea, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Take lapatinib on an empty stomach 1 hour before or 1 hour after a meal unless otherwise directed by your doctor. This will make it easier for your body to absorb the medication. The lapatinib dose is administered once daily and should not be divided. The usual dose of lapatinib is equal to 5 tablets. You may swallow each tablet one at a time, but take the entire lapatinib dose at the same time each day. If you are receiving therapy with lapatinib you should be advised to avoid grapefruits and grapefruit juice. Grapefruit can raise the levels of lapatinib in your body and lead to dangerous side effects.

Food may decrease the blood levels of brincidofovir. It is recommended that you take brincidofovir on an empty stomach, meaning no food should be eaten for at least two hours before or after taking brincidofovir. If necessary, you may take the oral tablets (but not the suspension formulation) with a low-fat meal. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.