Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- cedazuridine / decitabine
- palifermin
Interactions between your drugs
palifermin decitabine
Applies to: palifermin, cedazuridine / decitabine
ADJUST DOSING INTERVAL: In a clinical trial, administration of palifermin within 24 hours of chemotherapy resulted in increased severity and duration of oral mucositis, presumably due to increased sensitivity of the rapidly dividing epithelial cells in the immediate post-chemotherapy period.
MANAGEMENT: Palifermin should not be administered within 24 hours before, during infusion of, or within 24 hours after administration of myelotoxic chemotherapy.
References (1)
- (2004) "Product Information. Kepivance (palifermin)." Shire US Inc
Drug and food interactions
cedazuridine food
Applies to: cedazuridine / decitabine
ADJUST DOSING INTERVAL: There are no data regarding the concurrent administration of oral cedazuridine-decitabine with food.
MANAGEMENT: The manufacturer recommends that patients avoid eating for 2 hours before and 2 hours after administration of oral cedazuridine-decitabine.
References (1)
- (2020) "Product Information. Inqovi (cedazuridine-decitabine)." Taiho Oncology, Inc.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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