Drug Interaction Report

Nefazodone may increase the blood levels of osilodrostat. This may increase the risk and/or severity of serious and potentially life-threatening side effects such as hypocortisolism (low cortisol levels in the blood), QT prolongation (a heart condition that can lead to irregular heart rhythm), elevated levels of male hormones, high blood pressure, fluid retention, swelling, and hypokalemia (low potassium levels in the blood, which in severe cases can lead to muscle weakness, paralysis, breathing and swallowing difficulties (due to muscle paralysis), and irregular heart rhythm). Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Let your doctor know if you experience nausea, vomiting, abdominal pain, loss of appetite, fatigue, confusion, dizziness, lightheadedness, fainting, muscle weakness, muscle cramps, numbness or tingling, rapid or irregular heart beat, chest pain, and/or swelling in the legs or feet, as these may be symptoms of hypokalemia or other excessive effects of osilodrostat. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Alcohol can increase the nervous system side effects of nefazodone such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with nefazodone. Do not use more than the recommended dose of nefazodone, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.