Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- tafamidis
- Unasyn (ampicillin / sulbactam)
Interactions between your drugs
sulbactam tafamidis
Applies to: Unasyn (ampicillin / sulbactam), tafamidis
GENERALLY AVOID: Coadministration of sulbactam with inhibitors of the organic anion transporter 1 (OAT1) may increase the plasma concentrations and effects of sulbactam, which is a substrate of this transport protein and is predicted to have active secretion as a significant portion of its total clearance. However, clinical data are not available.
MANAGEMENT: The use of sulbactam with drugs that are inhibitors of OAT1, such as probenecid, is not recommended.
References (1)
- (2023) "Product Information. Xacduro (durlobactam-sulbactam)." La Jolla Pharmaceutical
Drug and food interactions
ampicillin food
Applies to: Unasyn (ampicillin / sulbactam)
ADJUST DOSING INTERVAL: Certain penicillins may exhibit reduced gastrointestinal absorption in the presence of food. The therapeutic effect of the antimicrobial may be reduced.
MANAGEMENT: The interacting penicillin should be administered one hour before or two hours after meals. Penicillin V and amoxicillin are not affected by food and may be given without regard to meals.
References (6)
- Neu HC (1974) "Antimicrobial activity and human pharmacology of amoxicillin." J Infect Dis, 129, s123-31
- Welling PG, Huang H, Koch PA, Madsen PO (1977) "Bioavailability of ampicillin and amoxicillin in fasted and nonfasted subjects." J Pharm Sci, 66, p. 549-52
- McCarthy CG, Finland M (1960) "Absorption and excretion of four penicillins." N Engl J Med, 263, p. 315-26
- Cronk GA, Wheatley WB, Fellers GF, Albright H (1960) "The relationship of food intake to the absorption of potassium alpha-phenoxyethyl penicillin and potassium phenoxymethyl penicillin from the gastrointestinal tract." Am J Med Sci, 240, p. 219-25
- Klein JO, Sabath LD, Finland M (1963) "Laboratory studies on oxacillin. I: in vitro activity against staphylococci and some other bacterial pathogens. II: absorption and urinary excretion in normal young." Am J Med Sci, 245, p. 399-411
- Neuvonen PJ, Elonen E, Pentikainen PJ (1977) "Comparative effect of food on absorption of ampicillin and pivampicillin." J Int Med Res, 5, p. 71-6
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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