Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Blenoxane (bleomycin)
- oxygen
Interactions between your drugs
bleomycin oxygen
Applies to: Blenoxane (bleomycin), oxygen
ADJUST DOSE: The use of oxygen in patients undergoing bleomycin treatment may increase the severity of bleomycin-associated pulmonary toxicity. Severe and fatal respiratory distress syndrome, pneumonitis, and pulmonary fibrosis have been reported. The interaction may be dose-dependent. Oxygen concentrations higher then 30% may increase the risk of pulmonary toxicity. A study reported that the use of lower oxygen concentrations (22% to 30%) decreased the incidence of respiratory distress syndrome during surgery. The mechanism is unknown.
MANAGEMENT: The manufacturer considers the use of pulmonary function tests with 100% oxygen to be contraindicated in bleomycin-treated patients, and recommends the use of pulmonary function tests with less than 21% oxygen. During general anesthesia, it is recommended that bleomycin-treated patients receive oxygen concentrations less than 30%.
References (1)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
Drug and food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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