Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- coagulation factor Xa
- Konyne 80 (factor ix complex)
Interactions between your drugs
factor IX complex coagulation factor Xa
Applies to: Konyne 80 (factor ix complex), coagulation factor Xa
GENERALLY AVOID: The safety of andexanet alfa (recombinant coagulation factor Xa) has not been evaluated in patients who received prothrombin complex concentrates, recombinant factor VIIa, or whole blood within seven days prior to the bleeding event, as they were excluded from clinical trials.
MANAGEMENT: Pro-coagulant factor treatments (e.g., 3- or 4-factor prothrombin complex concentrates (PCCs), activated PCC, recombinant factor VIIa, fresh frozen plasma) and whole blood should be avoided during treatment with andexanet alfa unless absolutely required.
References (3)
- (2022) "Product Information. Andexxa (coagulation factor Xa)." Portola Pharmaceuticals
- (2022) "Product Information. Ondexxya (coagulation factor Xa)." AstraZeneca UK Ltd
- (2023) "Product Information. Andexxa (andexanet alfa (factor Xa))." AstraZeneca Pty Ltd
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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