Drug Interaction Report
1 drug interaction and 9 additional warnings found for the following 2 drugs:
- flibanserin
- Zyrtec (cetirizine)
Drug interactions
Moderate drug interactions
Moderate:cetirizine flibanserin
Applies to: Zyrtec (cetirizine), flibanserin
Using flibanserin together with cetirizine may increase side effects such as:
- dizziness
- drowsiness
- fatigue
- difficulty concentrating
You should avoid the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery for at least 6 hours after taking flibanserin and until you know how the medications affect you.
Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Major food/lifestyle interactions
Major:Food/Lifestyle flibanserin
Applies to: flibanserin
Do not use alcohol too close to the dosing time of flibanserin. Doing so can cause excessive drowsiness and decreases in blood pressure, which may lead to:
- dizziness
- lightheadedness
- fainting
- accidental injury
What to do: Take flibanserin at bedtime to minimize the risk of these effects. It is recommended that you stop drinking alcohol at least two hours before taking flibanserin; otherwise, you should just skip the flibanserin dose that evening. Alcohol should not be consumed until at least the morning after taking flibanserin at bedtime.
Because grapefruit juice can significantly increase the blood levels of flibanserin, you should also avoid the consumption of grapefruit and grapefruit juice during treatment.
Talk to your healthcare provider if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Moderate food/lifestyle interactions
Moderate:Food/Lifestyle cetirizine
Applies to: Zyrtec (cetirizine)
Alcohol can increase the nervous system side effects of cetirizine such as:
- dizziness
- drowsiness
- difficulty concentrating
Some people may also experience impairment in thinking and judgment.
You should avoid or limit the use of alcohol while being treated with cetirizine.
Do not use more than the recommended dose of cetirizine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you.
Talk to your doctor or pharmacist if you have any questions or concerns.
Disease interactions
7 potential interactionsApplies to: 6 conditions, including Hypotension, Syncope, Liver Disease, Alcoholism, and Renal Dysfunction.
Acute Alcohol Intoxication
Moderate:Zyrtec
The cetirizine in Zyrtec has a moderate potential interaction with Acute Alcohol Intoxication.
Alcohol should be avoided when using cetirizine, and some other antihistamines. Cetirizine may produce drowsiness that may be increase by the use of alcohol, sedatives and tranquilizers.
Alcoholism
Major:flibanserin
Flibanserin has a major potential interaction with Alcoholism.
The use of flibanserin is contraindicated along with the ingestion of alcohol, as it increases the risk of hypotension and syncope. It is important to assess the likelihood of the patient abstaining from alcohol, taking into account the current and past drinking behavior.
Hypotension
Major:flibanserin
Flibanserin has a major potential interaction with Hypotension.
The use of flibanserin can cause hypotension and syncope. The benefits and risks of therapy should be considered in patients with preexisting conditions that predispose to hypotension. Flibanserin should be used with caution in these patients.
Liver Disease
Major:flibanserin
Flibanserin has a major potential interaction with Liver Disease.
Flibanserin may accumulate in patients with hepatic impairment. Therapy with flibanserin is contraindicated in patients with compromised hepatic function.
Moderate:Zyrtec
The cetirizine in Zyrtec has a moderate potential interaction with Liver Disease.
Cetirizine is eliminated primarily by the kidney but also undergoes metabolism in the liver to some extent. Patients with renal and/or liver disease may be at greater risk for adverse effects from cetirizine due to decreased drug clearance. The manufacturer recommends an initial dosage of 5 mg once daily in patients 6 years of age and older with decreased renal function (CrCl <= 30 mL/min, including those on hemodialysis) and/or impaired hepatic function. Cetirizine should preferably not be used in children less than 6 years of age with renal and/or hepatic impairment because of the difficulty in reliably administering doses smaller than 2.5 mg (1/2 teaspoonful) and a lack of pharmacokinetic and safety data in this population.
Renal Dysfunction
Moderate:Zyrtec
The cetirizine in Zyrtec has a moderate potential interaction with Renal Dysfunction.
Cetirizine is eliminated primarily by the kidney but also undergoes metabolism in the liver to some extent. Patients with renal and/or liver disease may be at greater risk for adverse effects from cetirizine due to decreased drug clearance. The manufacturer recommends an initial dosage of 5 mg once daily in patients 6 years of age and older with decreased renal function (CrCl <= 30 mL/min, including those on hemodialysis) and/or impaired hepatic function. Cetirizine should preferably not be used in children less than 6 years of age with renal and/or hepatic impairment because of the difficulty in reliably administering doses smaller than 2.5 mg (1/2 teaspoonful) and a lack of pharmacokinetic and safety data in this population.
Syncope
Major:flibanserin
Flibanserin has a major potential interaction with Syncope.
The use of flibanserin can cause hypotension and syncope. The benefits and risks of therapy should be considered in patients with preexisting conditions that predispose to hypotension. Flibanserin should be used with caution in these patients.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.