Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- isavuconazonium
- Myhibbin (mycophenolate mofetil)
Interactions between your drugs
mycophenolate mofetil isavuconazonium
Applies to: Myhibbin (mycophenolate mofetil), isavuconazonium
MONITOR: Coadministration with isavuconazonium sulfate (prodrug of isavuconazole) may increase the bioavailability of mycophenolic acid. The proposed mechanism is isavuconazole inhibition of the UGT-mediated metabolism of mycophenolic acid. When a single 1 gram dose of mycophenolate mofetil was administered to healthy volunteers following multiple dosing of isavuconazonium sulfate, mycophenolic acid systemic exposure (AUC) increased by nearly 40%.
MANAGEMENT: Caution is advised when mycophenolic acid is prescribed with isavuconazonium sulfate. Clinical and laboratory monitoring are recommended following the addition or withdrawal of isavuconazonium sulfate, and the mycophenolic acid dosage adjusted as necessary.
References (1)
- (2015) "Product Information. Cresemba (isavuconazonium)." Astellas Pharma US, Inc
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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