Drug Interaction Report

Talk to your doctor before using asparaginase Escherichia coli together with acitretin. Combining these medications may increase the risk of side effects such as liver damage. You may need more frequent monitoring by your doctor to safely use both medications. Let your doctor know immediately if you develop right upper quadrant pain, increasing abdominal size, fever, swelling, rash, itching, loss of appetite, fatigue, nausea, vomiting, dark urine, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Take acitretin with food. Women must avoid all drinks, food, and medicines (including over-the-counter products) that contain alcohol while taking acitretin or for 2 months after stopping treatment. Alcoholic beverages increase the risk for birth defects while taking acitretin. Acitretin can cause severe, life-threatening birth defects if the mother takes the medication during pregnancy. Never use acitretin if you are pregnant. Both a primary and a secondary form of birth control must be used together and for at least 3 years after stopping therapy. Talk with your doctor about other possible birth control methods while you are taking acitretin. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor.

Talk to your doctor before using asparaginase Escherichia coli together with ethanol (alcohol). Combining these medications may increase the risk of side effects such as liver damage. You may need more frequent monitoring by your doctor to safely use both medications. Let your doctor know immediately if you develop right upper quadrant pain, increasing abdominal size, fever, swelling, rash, itching, loss of appetite, fatigue, nausea, vomiting, dark urine, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.