Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- C1 esterase inhibitor (human)
- Retavase (reteplase)
Interactions between your drugs
reteplase C1 esterase inhibitor, human
Applies to: Retavase (reteplase), C1 esterase inhibitor (human)
GENERALLY AVOID: C1 esterase inhibitors inhibit proteases in the coagulation/fibrinolytic system and may inhibit tissue plasminogen activators (tPAs). Complexation of C1 esterase inhibitor and tPA has been observed in scientific studies. However, the interaction has not been studied during clinical use of these agents concomitantly.
MANAGEMENT: Simultaneous administration of a C1 esterase inhibitor and a tPA should preferably be avoided.
References (1)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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