Drug Interaction Report
4 potential interactions and/or warnings found for the following 2 drugs:
- alvimopan
- methylnaltrexone
Interactions between your drugs
methylnaltrexone alvimopan
Applies to: methylnaltrexone, alvimopan
Using methylnaltrexone together with alvimopan may increase the risk of opioid withdrawal. Symptoms may include sweating, tearing, runny nose, chills, diarrhea, abdominal pain, nausea, vomiting, anxiety, insomnia, irritability, restlessness, and yawning. These medications should generally not be used together. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
methylnaltrexone food
Applies to: methylnaltrexone
Food may reduce the absorption of methylnaltrexone when taken orally, which may lead to lower blood levels of the medication and possibly reduced effectiveness. You should take oral preparations of methylnaltrexone on an empty stomach at least 30 minutes before your first meal of the day.
alvimopan food
Applies to: alvimopan
Information for this minor interaction is available on the professional version.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Peripheral opioid receptor antagonists
Therapeutic duplication
The recommended maximum number of medicines in the 'peripheral opioid receptor antagonists' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'peripheral opioid receptor antagonists' category:
- alvimopan
- methylnaltrexone
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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