Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- tacrine
- viloxazine
Interactions between your drugs
tacrine viloxazine
Applies to: tacrine, viloxazine
GENERALLY AVOID: Coadministration with potent inhibitors of CYP450 1A2 may significantly increase the plasma concentrations of tacrine, which has been shown to be primarily metabolized by the isoenzyme.
MANAGEMENT: Concomitant use of tacrine with potent CYP450 1A2 inhibitors should generally be avoided. If coadministration is necessary, monitor for side effects, such as nausea, vomiting, sweating, and diarrhea. The risk of hepatotoxicity may be increased.
References (2)
- Becquemont L, Ragueneau I, LeBot MA, Riche C, FunckBrentano C, Jaillon P (1997) "Influence of the CYP1A2 inhibitor fluvoxamine on tacrine pharmacokinetics in humans." Clin Pharmacol Ther, 61, p. 619-27
- (2021) "Product Information. Qelbree (viloxazine)." Supernus Pharmaceuticals Inc
Drug and food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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