Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- tacrine
- Theocon Elixir (guaifenesin / oxtriphylline)
Interactions between your drugs
oxtriphylline tacrine
Applies to: Theocon Elixir (guaifenesin / oxtriphylline), tacrine
ADJUST DOSE: Tacrine may increase plasma theophylline levels twofold and increase the elimination half-life of theophylline. The mechanism is probably related to the fact that both agents are metabolized by CYP450 1A2. Other hepatically metabolized methylxanthines may also be affected.
MANAGEMENT: If tacrine and a theophylline must be used concomitantly, dosage reductions are recommended, as is close observation for evidence of altered clinical and laboratory effects. Patients should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat to their physicians.
References (1)
- (2001) "Product Information. Cognex (tacrine)." Parke-Davis
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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