Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Arduan (pipecuronium)
- bacitracin
Interactions between your drugs
pipecuronium bacitracin
Applies to: Arduan (pipecuronium), bacitracin
MONITOR: Like other polypeptide antibiotics, systemically administered bacitracin may prolong apnea and respiratory paralysis associated with the use of nondepolarizing neuromuscular blocking agents. The mechanism may involve decreased intracellular potassium or decreased ionized serum calcium, as intravenous calcium administration has been reported to be helpful in reversing paralysis caused by polymyxin B in some cases.
MANAGEMENT: Patients should be closely monitored for prolonged or excessive neuromuscular blockade.
References (2)
- Kronenfeld MA, Thomas SJ, Turndorf H (1986) "Recurrence of neuromuscular blockade after reversal of vecuronium in a patient receiving polymyxin/amikacin sternal irrigation." Anesthesiology, 65, p. 93-4
- Huang KC, Heise A, Shrader AK, Tsueda K (1990) "Vancomycin enhances the neuromuscular blockade of vecuronium." Anesth Analg, 71, p. 194-6
Drug and food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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