Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- pentoxifylline
- Toradol IV/IM (ketorolac)
Interactions between your drugs
ketorolac pentoxifylline
Applies to: Toradol IV/IM (ketorolac), pentoxifylline
CONTRAINDICATED: The concomitant use of pentoxifylline and ketorolac may increase the risk of bleeding. Bleeding events have been reported in postoperative patients who were receiving both drugs, although causality was not established. Pentoxifylline and ketorolac individually have been associated with prothrombin time prolongations and bleeding.
MANAGEMENT: Concurrent use is considered contraindicated.
References (1)
- (2002) "Product Information. Toradol (ketorolac)." Roche Laboratories
Drug and food interactions
ketorolac food
Applies to: Toradol IV/IM (ketorolac)
GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.
MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.
References (1)
- (2002) "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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