Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- levobupivacaine
- Tafinlar (dabrafenib)
Interactions between your drugs
levobupivacaine dabrafenib
Applies to: levobupivacaine, Tafinlar (dabrafenib)
Coadministration with inducers of CYP450 1A2 and/or 3A4 may decrease the plasma concentrations of levobupivacaine, which is primarily metabolized by these isoenzymes. However, the clinical significance is unknown, as the interaction has not been studied nor reported in the medical literature.
References (1)
- (2001) "Product Information. Chirocaine (levobupivacaine)." Organon
Drug and food/lifestyle interactions
dabrafenib food/lifestyle
Applies to: Tafinlar (dabrafenib)
ADJUST DOSING INTERVAL: Food may reduce as well as delay the absorption of dabrafenib. In study subjects, administration of dabrafenib with a high-fat meal decreased peak plasma concentration (Cmax) and systemic exposure (AUC) by 51% and 31%, respectively, and delayed median Tmax by approximately 3.6 hours compared to administration in the fasted state.
MANAGEMENT: Dabrafenib should be taken at least 1 hour before or 2 hours after a meal.
References (1)
- (2013) "Product Information. Tafinlar (dabrafenib)." GlaxoSmithKline
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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