Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- lepirudin
- NexoBrid (anacaulase topical)
Interactions between your drugs
lepirudin anacaulase topical
Applies to: lepirudin, NexoBrid (anacaulase topical)
MONITOR: Concomitant use of anacaulase with anticoagulants or other drugs affecting coagulation may increase the risk of bleeding. According to the manufacturer, in vitro and animal data suggest that bromelain, a component of anacaulase-bcdb, can promote fibrinolysis. Reduced platelet aggregation and plasma fibrinogen levels and moderately increased partial thromboplastin and prothrombin times have also been reported following oral bromelain administration.
MANAGEMENT: Caution is advised if anacaulase is used in patients on anticoagulant therapy or other drugs affecting coagulation. Clinical and laboratory monitoring for coagulation abnormalities and bleeding is recommended.
References (1)
- (2022) "Product Information. Nexobrid (anacaulase topical)." Vericel Corporation
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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