Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- interferon alfa-n1
- Lipodox 50 (doxorubicin liposomal)
Interactions between your drugs
DOXOrubicin liposomal interferon alfa-n1
Applies to: Lipodox 50 (doxorubicin liposomal), interferon alfa-n1
Human lymphoblastoid interferon has been shown to enhance the antitumor activity of doxorubicin and cyclophosphamide in animal models by delaying the G2 cell division phase and increasing the number of cells in the S phase. The clinical significance of this finding is unknown.
References (2)
- Balkwill FR, Mowshowitz S, Seilman SS, et al. (1984) "Positive interactions between interferon and chemotherapy due to direct tumor action rather than effects on host drug-metabolizing enzymes." Cancer Res, 44, p. 5249-55
- Kang Y, Perry RR (1993) "Modulatory effects of tamoxifen and recombinant human alpha- interferon on doxorubicin resistance." Cancer Res, 53, p. 3040-5
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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