Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- agalsidase beta
- Septopal (gentamicin)
Interactions between your drugs
gentamicin agalsidase beta
Applies to: Septopal (gentamicin), agalsidase beta
GENERALLY AVOID: Amiodarone, chloroquine, and gentamicin may have the potential to inhibit intracellular alpha-galactosidase activity, thereby reducing the pharmacologic effects of agalsidase alfa, agalsidase beta, and pegunigalsidase alfa. Clinical data have not been reported.
MANAGEMENT: Agalsidase and pegunigalsidase should not be coadministered with amiodarone, chloroquine, or gentamicin.
References (6)
- (2004) "Product Information. Replagal (agalsidase alfa)." Transkaryotic Therapies Inc
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
- Cerner Multum, Inc. (2015) "Canadian Product Information."
- (2021) "Product Information. Fabrazyme (agalsidase beta)." Genzyme Corporation, SUPPL-5309
- (2023) "Product Information. Elfabrio (pegunigalsidase alfa)." Chiesi USA, Inc
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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