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Croscarmellose Sodium

Medically reviewed by Last updated on Nov 2, 2023.

Excipient (pharmacologically inactive substance)

What is it?

Croscarmellose sodium, or sodium CMC, is a cross-linked polymer of carboxymethylcellulose sodium. It appears as white, fibrous, free-flowing powder, and is used commonly as an FDA-approved disintegrant in pharmaceutical manufacturing. Disintegrants facilitate the breakup of a tablet in the intestinal tract after oral administration. Cross-linking allows enhanced bioavailability of the drug through superior drug dissolution. Without a disintegrant, tablets may not dissolve appropriately and may effect the amount of active ingredient absorbed, thereby decreasing effectiveness.[1]

According to the FDA Select Committee on GRAS food substances, carboxymethylcellulose sodium is virtually unabsorbed. Caroxymethylcellulose sodium is generally regarded as safe when used in normal quantities.[2]

List of medications using Croscarmellose Sodium


  1. Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 Accessed 08/19/2011
  2. FDA’s SCOGS database; corn starch, Report No. 977050-51-3, 1979.; ID Code: 72; Accessed October 17, 2011

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.