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Ascorbyl Palmitate

Medically reviewed by Last updated on Nov 6, 2023.

Excipient (pharmacologically inactive substance)

What is it?

Ascorbyl palmitate (C22H38O7) is a fat-soluble form of vitamin C (antioxidant) used in some pharmaceutical products, such as suppositories. It may also be used in topical formulations because it is more stable than some water-soluble forms of vitamin C.[1] According to the FDA, it is also used as a preservative in foods, such as in potato chips. Ascorbyl palmitate is listed on the FDA list of generally recognized as safe (GRAS) substances.[2] Ascorbyl palmitate may be marketed individually as a vitamin C replacement with the name of vitamin C ester, but should not be confused with Ester-C, which is primarily calcium ascorbate.

List of medications using Ascorbyl Palmitate


  1. Austria R. et al. Stability of vitamin C derivatives in solution and in topical formulations. Journal of Pharmacology and Biomedical Analysis. 1997;15:795-801.
  2. FDA’s SCOGS database; L-ascorbic acid; SCOGS-Report Number: 59; Accessed March 26, 2012.

Further information

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