Is there an over-the-counter or holistic supplement comparable to Prednisone? I have had contact dermatitis on and off for over 40 years. It mainly affects my hands and I have keep it in check with over-the-counter Hydrocortisone cream Since moving in with my son four years ago, I have been having problematic flare-up spring and fall due to air-born allergens. I do not have medical insurance … I pay out-of-pocket for all my doctor visits, which is becoming very expensive just to get a prescription for Prednisone (10 mg tablets). I respond very quickly to Prednisone and have no side-effects … but the doctor will not prescribe it without a $125.00 office visit.