Sepiapterin and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with sepiapterin.
Moderate
Sepiapterin Food/Lifestyle
Moderate Food Interaction
ADJUST DOSING INTERVAL: Food enhances the oral bioavailability of sepiapterin. When given with a high-fat meal, sepiapterin peak plasma concentration (Cmax) increased by 221% to 226% and systemic exposure (AUC) increased by 251% to 284%, compared to the fasted state.
MANAGEMENT: Sepiapterin should be administered with food.
References (1)
- (2025) "Product Information. Sephience (sepiapterin)." PTC Therapeutics, Inc.
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Sepiapterin drug interactions
There are 35 drug interactions with sepiapterin.
Sepiapterin disease interactions
There is 1 disease interaction with sepiapterin which include:
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- Drug class: miscellaneous metabolic agents
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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