Antidotum Thallii-Heyl and Alcohol/Food Interactions

ADJUST DOSING INTERVAL: Food may enhance the effectiveness of Prussian blue insoluble by stimulating bile production and enterohepatic circulation, which increases the amount of cesium and thallium in the gastrointestinal lumen for binding with Prussian blue followed by elimination in the feces.

MONITOR: Prussian blue insoluble acts by ion exchange, adsorption, and mechanical trapping within its crystal structure. Theoretically, it may bind some orally administered therapeutic drugs.

MANAGEMENT: Prussian blue insoluble may be taken with food to stimulate excretion of cesium or thallium. As appropriate, blood levels of concomitantly administered oral medications and/or clinical response should be monitored, and the dosages adjusted as necessary.