Guaifenesin / oxtriphylline and Alcohol / Food Interactions
There is 1 alcohol/food/lifestyle interaction with guaifenesin / oxtriphylline:
High Blood Pressure (Hypertension)
Moderate Potential Hazard, Moderate plausibility
methylxanthines - tachyarrhythmias
The use of theophyllines is associated with an increase in heart rate which may progress to supraventricular tachycardia or ventricular arrhythmia at high serum drug concentrations. Appearance of cardiac adverse effects is generally an indication of theophylline toxicity, although patients with a history of tachyarrhythmias may be more susceptible to the chronotropic effect of these drugs. Therapy with theophyllines should be administered cautiously in such patients. Caution is also advised in patients with hypertension, hyperthyroidism, angina pectoris, or recent myocardial infarction, since high dosages of the drugs are associated with positive inotropic as well as chronotropic effects. Clinical monitoring of serum drug concentrations is recommended to prevent toxicity.
- Levine JH, Michael JR, Guarnieri T "Multifocal atrial tachycardia: a toxic effect of theophylline." Lancet 1 (1985): 12-4
- Sessler CN "Theophylline toxicity: clinical features of 116 consecutive cases." Am J Med 88 (1990): 567-76
- Bittar G, Friedman HS "The arrhythmogenicity of theophylline: a multivariate analysis of clinical determinants." Chest 99 (1991): 1415-20
guaifenesin / oxtriphylline drug Interactions
There are 310 drug interactions with guaifenesin / oxtriphylline
guaifenesin / oxtriphylline disease Interactions
There are 7 disease interactions with guaifenesin / oxtriphylline which include:
Drug Interaction Classification
|No information available.|
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