Everolimus and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with everolimus.
Everolimus Food/Lifestyle
Moderate Food Interaction
GENERALLY AVOID: Grapefruit juice may significantly increase the plasma concentrations of orally administered everolimus. The mechanism is inhibition of CYP450 3A4 and P-glycoprotein activity in the gut wall by certain compounds present in grapefruit.
MANAGEMENT: Patients treated with everolimus should avoid consumption of grapefruit and grapefruit juice.
References (1)
- (2009) "Product Information. Afinitor (everolimus)." Novartis Pharmaceuticals
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Everolimus High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)
Moderate Potential Hazard, Moderate plausibility
mTOR inhibitors - cholesterol
Elevations in cholesterol and triglyceride levels have been reported in patients taking inhibitors of mTOR (mammalian target of rapamycin). Monitoring of fasting lipid profile is recommended prior to the start of therapy and periodically thereafter. Clinicians should achieve control of lipid levels before initiating therapy with these agents.
References (2)
- (2007) "Product Information. Torisel (temsirolimus)." Wyeth-Ayerst Laboratories
- (2009) "Product Information. Afinitor (everolimus)." Novartis Pharmaceuticals
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Everolimus drug interactions
There are 553 drug interactions with everolimus.
Everolimus disease interactions
There are 8 disease interactions with everolimus which include:
- liver disease
- vaccination
- renal disease
- hematologic abnormalities
- blood glucose
- cholesterol
- Infections
- wound complication
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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