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Afinitor and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with Afinitor (everolimus).


Everolimus Food

Moderate Food Interaction

Grapefruit juice can increase the blood levels and effects of everolimus. You should not drink grapefruit juice or eat grapefruits during your treatment with everolimus. Orange juice is not expected to interact.

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Everolimus High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)

Moderate Potential Hazard, Moderate plausibility

mTOR inhibitors - cholesterol

Elevations in cholesterol and triglyceride levels have been reported in patients taking inhibitors of mTOR (mammalian target of rapamycin). Monitoring of fasting lipid profile is recommended prior to the start of therapy and periodically thereafter. Clinicians should achieve control of lipid levels before initiating therapy with these agents.


  1. (2007) "Product Information. Torisel (temsirolimus)." Wyeth-Ayerst Laboratories
  2. (2009) "Product Information. Afinitor (everolimus)." Novartis Pharmaceuticals

Afinitor drug interactions

There are 519 drug interactions with Afinitor (everolimus).

Afinitor disease interactions

There are 8 disease interactions with Afinitor (everolimus) which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.