Afinitor and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with Afinitor (everolimus).
Moderate Food Interaction
Grapefruit juice can increase the blood levels and effects of everolimus. You should not drink grapefruit juice or eat grapefruits during your treatment with everolimus. Orange juice is not expected to interact.
High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)
Moderate Potential Hazard, Moderate plausibility
mTOR inhibitors - cholesterol
Elevations in cholesterol and triglyceride levels have been reported in patients taking inhibitors of mTOR (mammalian target of rapamycin). Monitoring of fasting lipid profile is recommended prior to the start of therapy and periodically thereafter. Clinicians should achieve control of lipid levels before initiating therapy with these agents.
- "Product Information. Torisel (temsirolimus)." Wyeth-Ayerst Laboratories (2007):
- "Product Information. Afinitor (everolimus)." Novartis Pharmaceuticals (2009):
Afinitor drug interactions
There are 459 drug interactions with Afinitor (everolimus).
Afinitor disease interactions
There are 8 disease interactions with Afinitor (everolimus) which include:
- liver disease
- renal disease
- hematologic abnormalities
- blood glucose
- wound complication
More about Afinitor (everolimus)
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- Drug class: mTOR inhibitors
- FDA approval history
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.