Crinecerfont and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with crinecerfont.
Crinecerfont Food/Lifestyle
Moderate Food Interaction
ADJUST DOSING INTERVAL: Coadministration with food increases the oral bioavailability of crinecerfont. Administration of crinecerfont capsules and oral solution with a high-fat meal (800 to 1000 calories, 50% fat), increased crinecerfont peak plasma concentration (Cmax) by 4.9-fold and 8.6-fold, respectively, and systemic exposure (AUC) by 3.3-fold and 8.3-fold, respectively, compared to administration under fasting conditions.
MANAGEMENT: Crinecerfont should be administered twice daily with a meal in the morning and evening without regard to fat or calorie content.
References (1)
- (2024) "Product Information. Crenessity (crinecerfont)." Neurocrine Biosciences, Inc.
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Crinecerfont drug interactions
There are 31 drug interactions with crinecerfont.
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- Drug class: adrenal corticosteroid inhibitors
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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