Adenocaine PF (adenosine / lidocaine / magnesium sulfate) and Alcohol/Food Interactions
There are 3 alcohol/food/lifestyle interactions with Adenocaine PF (adenosine / lidocaine / magnesium sulfate) which include:
Moderate Drug Interaction
Ask your doctor before using adenosine together with caffeine. Using these medications together can decrease the effects of adenosine. It is recommended that caffeine including caffeine be avoided for 12 to 24 hours before adenosine administration. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Minor Drug Interaction
Information for this minor interaction is available on the professional version.
Moderate Food Interaction
Consumer information for this interaction is not currently available.
ADJUST DOSING INTERVAL: Caffeine and other xanthine derivatives (e.g., theophylline) are nonspecific, competitive antagonists of adenosine receptors and may interfere with the hemodynamic effects of adenosine. There have been case reports of patients receiving theophylline who required higher than normal dosages of adenosine for the treatment of paroxysmal supraventricular tachycardia. In studies of healthy volunteers, caffeine and theophylline have been shown to reduce the cardiovascular response to adenosine infusions (i.e., heart rate increases, vasodilation, blood pressure changes), and theophylline has also been shown to attenuate adenosine-induced respiratory effects and chest pain/discomfort.
MANAGEMENT: Clinicians should be aware that adenosine may be less effective in the presence of xanthine derivatives including caffeine. Patients should avoid consumption of caffeine-containing products for at least 12 hours, preferably 24 hours, prior to administration of adenosine for myocardial perfusion imaging.
- Minton NA, Henry JA "Pharmacodynamic interactions between infused adenosine and oral theophylline." Hum Exp Toxicol 10 (1991): 411-8
- "Product Information. Adenoscan (adenosine)." Fujisawa, Deerfield, IL.
- "Product Information. Adenocard (adenosine)." Fujisawa, Deerfield, IL.
- Smits P, Schouten J, Thien T "Respiratory stimulant effects of adenosine in man after caffeine and enprofylline." Br J Clin Pharmacol 24 (1987): 816-9
- Conti CR "Adenosine: clinical pharmacology and applications." Clin Cardiol 14 (1991): 91-3
- "Multum Information Services, Inc. Expert Review Panel"
Adenocaine PF (adenosine / lidocaine / magnesium sulfate) drug interactions
There are 498 drug interactions with Adenocaine PF (adenosine / lidocaine / magnesium sulfate)
Adenocaine PF (adenosine / lidocaine / magnesium sulfate) disease interactions
There are 17 disease interactions with Adenocaine PF (adenosine / lidocaine / magnesium sulfate) which include:
- AV node dysfunction
- cardiovascular dysfunction
- proarrhythmic effects
- inflammatory bowel disease
- intestinal obstruction disorders
- hepatic dysfunction
- renal dysfunction
- sinus/AV node dysfunction
- cardiac disease
- renal dysfunction
- myasthenia gravis
- electrolyte imbalance
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.