Can you take Treosulfan with Ubrogepant?
1 drug interaction and 6 additional warnings found for the following 2 drugs:
- treosulfan
- ubrogepant
Drug interactions
Moderate drug interactions
Moderate:
treosulfan ubrogepant
Applies to: treosulfan and ubrogepant
Treosulfan may increase the blood levels and effects of ubrogepant.
Contact your doctor if your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring to safely use both medications.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
ubrogepant Food/Lifestyle
Applies to: ubrogepant
Grapefruit and grapefruit juice can increase the blood levels of ubrogepant. This may increase side effects such as nausea and sleepiness.
Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe an alternative that does not interact, or you may need a different dose to safely use your medication with grapefruit and grapefruit juice.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
5 potential interactions Applies to: 3 conditions, including Seizures, Liver Disease, and Renal Dysfunction.
Liver Disease
Moderate:
treosulfan
Treosulfan has a moderate potential interaction with Liver Disease.
Treosulfan has not been studied in patients with moderate or severe liver and renal dysfunction.
Moderate:
ubrogepant
Ubrogepant has a moderate potential interaction with Liver Disease.
Care should be exercised when using ubrogepant in patients with severe hepatic impairment. Dose adjustment is recommended for these patients. No dose adjustment is recommended for patients with mild or moderate hepatic impairment.
Renal Dysfunction
Moderate:
treosulfan
Treosulfan has a moderate potential interaction with Renal Dysfunction.
Treosulfan has not been studied in patients with moderate or severe liver and renal dysfunction.
Moderate:
ubrogepant
Ubrogepant has a moderate potential interaction with Renal Dysfunction.
It is recommended to avoid the use of ubrogepant in patients with end-stage renal disease (CrCl <15 mL/min). No dosing recommendations can be made for these patients. A dose adjustment is recommended for patients with severe renal impairment (CrCl 15-29 mL/min). No dose adjustments are recommended for patients with mild or moderate renal impairment.
Seizures
Moderate:
treosulfan
Treosulfan has a moderate potential interaction with Seizures.
There have been reports of seizures in patients following treatment with treosulfan. Patients should be monitored for signs of neurological adverse reactions, and clonazepam prophylaxis may be considered for patients at higher risk for seizures, including infants.
Report options
More resources
treosulfan
A total of 547 drugs are known to interact with treosulfan.
- Treosulfan is in the drug class alkylating agents.
- Treosulfan is used to treat Stem Cell Transplant Conditioning.
ubrogepant
A total of 270 drugs are known to interact with ubrogepant.
- Ubrogepant is in the drug class CGRP inhibitors.
- Ubrogepant is used to treat the following conditions:
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.