Drug Interactions between riociguat and TNKase
This report displays the potential drug interactions for the following 2 drugs:
- riociguat
- TNKase (tenecteplase)
Interactions between your drugs
No interactions were found between riociguat and TNKase. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
riociguat
A total of 283 drugs are known to interact with riociguat.
- Riociguat is in the drug class vasodilators.
- Riociguat is used to treat Pulmonary Arterial Hypertension.
TNKase
A total of 151 drugs are known to interact with TNKase.
- Tnkase is in the drug class thrombolytics.
- Tnkase is used to treat Heart Attack.
Drug and food interactions
riociguat food
Applies to: riociguat
ADJUST DOSE: Smoking may decrease the plasma concentrations of riociguat. The proposed mechanism is induction of the CYP450 1A1-mediated metabolism of riociguat by polycyclic aromatic hydrocarbons present in cigarette smoke. CYP450 1A1 is responsible for the formation of the major active metabolite, M1, which has just 1/3 to 1/10 the pharmacologic activity of riociguat. According to the product labeling, plasma concentrations of riociguat are reduced by 50% to 60% in smokers compared to nonsmokers.
MANAGEMENT: Riociguat dosages higher than 2.5 mg three times a day may be considered in cigarette smokers, if tolerated, so as to match the exposure seen in nonsmoking patients. However, safety and effectiveness of higher dosages have not been established. A dosage reduction should be considered in patients who stop smoking during treatment with riociguat.
References
- "Product Information. Adempas (riociguat)." Bayer Pharmaceutical Inc (2013):
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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