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Drug Interactions between Ribasphere and ribavirin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

No interactions were found between Ribasphere and ribavirin. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Ribasphere

A total of 18 drugs are known to interact with Ribasphere.

ribavirin

A total of 18 drugs are known to interact with ribavirin.

Drug and food interactions

Moderate

ribavirin food

Applies to: Ribasphere (ribavirin) and ribavirin

ADJUST DOSING INTERVAL: Food enhances the oral absorption and bioavailability of ribavirin. Administration of a single oral dose of ribavirin following a high-fat meal delayed absorption (Tmax was doubled) but increased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) by up to 70% compared to administration in the fasting state.

MANAGEMENT: To ensure maximal oral absorption, ribavirin should be administered with or immediately after a meal.

References

  1. "Product Information. Copegus (ribavirin)." Roche Laboratories (2003):
  2. "Product Information. Rebetol (ribavirin)." Schering-Plough Corporation (2004):

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Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Imp dehydrogenase inhibitors

Therapeutic duplication

The recommended maximum number of medicines in the 'IMP dehydrogenase inhibitors' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'IMP dehydrogenase inhibitors' category:

  • Ribasphere (ribavirin)
  • ribavirin

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer