Phenytoin Drug Interactions
Currently displaying 561 drugs known to have a moderate interaction with phenytoin.
Moderate interactions with phenytoin
Note: Showing generic names only.
A
- acarbose
- acetaminophen
- acetohexamide
- acetylcarbromal
- acrivastine
- acyclovir
- adalimumab
- afatinib
- albendazole
- albiglutide
- alefacept
- alfentanil
- alogliptin
- alprazolam
- aluminum carbonate
- aluminum hydroxide
- aminophylline
- amitriptyline
- amobarbital
- amoxapine
- amprenavir
- anakinra
- anisindione
- apalutamide
- apomorphine
- apraclonidine ophthalmic
- aprepitant
- aprocitentan
- armodafinil
- artesunate
- asenapine
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- atazanavir
- atorvastatin
- atracurium
- avanafil
- azatadine
- azelastine nasal
B
- baclofen
- benoxinate ophthalmic
- benzocaine topical
- benztropine
- betamethasone
- betrixaban
- bexagliflozin
- bimekizumab
- binimetinib
- biperiden
- black cohosh
- bleomycin
- blinatumomab
- bosentan
- botulism immune globulin
- brentuximab
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromfenac
- bromocriptine
- brompheniramine
- budesonide
- bupivacaine
- bupivacaine liposome
- bupropion
- busulfan
- butabarbital
- butalbital
C
- cabazitaxel
- calaspargase pegol
- calcifediol
- calcitriol
- calcium carbonate
- canagliflozin
- canakinumab
- cannabidiol
- cannabis
- capecitabine
- carbamazepine
- carbetapentane
- carbinoxamine
- carboplatin
- carisoprodol
- carmustine
- celecoxib
- certolizumab
- cetirizine
- charcoal
- chlophedianol
- chloral hydrate
- chloramphenicol
- chloramphenicol ophthalmic
- chloramphenicol otic
- chlordiazepoxide
- chlormezanone
- chloroprocaine
- chloroprocaine ophthalmic
- chloroquine
- chlorotrianisene
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorpropamide
- chlorzoxazone
- cholecalciferol
- ciprofloxacin
- cisatracurium
- cisplatin
- citalopram
- cladribine
- clarithromycin
- clemastine
- clindamycin
- clobazam
- clofarabine
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clozapine
- cocaine nasal
- cocaine topical
- codeine
- colesevelam
- conjugated estrogens
- cortisone
- cyclizine
- cyclobenzaprine
- cyclophosphamide
- cycloserine
- cyclosporine
- cyproheptadine
- cytomegalovirus immune globulin
D
- dabrafenib
- daclizumab
- dantrolene
- daridorexant
- darifenacin
- deferasirox
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexamethasone
- dexbrompheniramine
- dexmedetomidine
- dextromethorphan
- dezocine
- diazepam
- diazoxide
- dibucaine topical
- dicumarol
- difelikefalin
- digitoxin
- digoxin
- dihydroergotamine
- dihydrotachysterol
- dihydroxyaluminum sodium carbonate
- dimenhydrinate
- diphenhydramine
- disopyramide
- disulfiram
- divalproex sodium
- docetaxel
- donepezil
- dopamine
- doxacurium
- doxepin
- doxepin topical
- doxercalciferol
- doxorubicin
- doxorubicin liposomal
- doxycycline
- doxylamine
- dronabinol
- droperidol
- dulaglutide
- duloxetine
E
- edoxaban
- efavirenz
- elagolix
- elranatamab
- emapalumab
- empagliflozin
- enfortumab vedotin
- entacapone
- enzalutamide
- epcoritamab
- epirubicin
- ergocalciferol
- ergonovine
- ergotamine
- ertugliflozin
- erythromycin
- escitalopram
- eslicarbazepine
- esomeprazole
- estazolam
- esterified estrogens
- estradiol
- estradiol topical
- estrone
- estropipate
- eszopiclone
- etanercept
- ethanol
- ethchlorvynol
- ethosuximide
- etidocaine
- etoposide
- etranacogene dezaparvovec
- exemestane
- exenatide
- ezogabine
F
- famotidine
- felbamate
- fenfluramine
- fenofibrate
- fesoterodine
- fidanacogene elaparvovec
- flavoxate
- fludrocortisone
- fluorouracil
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- folic acid
- fosamprenavir
- fosaprepitant
G
- gabapentin
- gabapentin enacarbil
- ginkgo
- glimepiride
- glipizide
- glofitamab
- glyburide
- golimumab
- guselkumab
H
- halazepam
- hepatitis b immune globulin
- heroin
- hydrocortisone
- hydromorphone
- hydroxychloroquine
- hydroxyprogesterone
- hydroxyzine
I
- iloperidone
- imipramine
- immune globulin intramuscular
- immune globulin intravenous
- immune globulin intravenous and subcutaneous
- immune globulin subcutaneous
- indinavir
- infliximab
- influenza virus vaccine, inactivated
- insulin
- insulin aspart
- insulin aspart protamine
- insulin degludec
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin inhalation, rapid acting
- insulin isophane
- insulin lispro
- insulin lispro protamine
- insulin regular
- insulin zinc
- insulin zinc extended
- interferon beta-1a
- interferon beta-1b
- isocarboxazid
- isoniazid
- isotretinoin
- itraconazole
- ixekizumab
K
L
- l-methylfolate
- lamotrigine
- lanthanum carbonate
- lasmiditan
- lesinurad
- letermovir
- leucovorin
- levamisole
- levobupivacaine
- levocetirizine
- levodopa
- levoleucovorin
- levomefolate calcium
- levorphanol
- levothyroxine
- levothyroxine / liothyronine
- lidocaine
- lidocaine ophthalmic
- lidocaine otic
- lidocaine topical
- linagliptin
- liothyronine
- liotrix
- liraglutide
- lixisenatide
- lofexidine
- lorazepam
- losartan
M
- macimorelin
- magaldrate
- magnesium carbonate
- magnesium hydroxide
- magnesium oxide
- maprotiline
- mebendazole
- meclizine
- medroxyprogesterone
- megestrol
- melatonin
- meperidine
- mephobarbital
- mepivacaine
- meprobamate
- mesoridazine
- metaxalone
- metformin
- methdilazine
- methocarbamol
- methohexital
- methotrexate
- methotrimeprazine
- methsuximide
- methylergonovine
- methylprednisolone
- methysergide maleate
- metoclopramide
- metocurine
- metronidazole
- metyrosine
- mexiletine
- miconazole
- midazolam
- mifepristone
- miglitol
- mirtazapine
- mitotane
- mivacurium
- modafinil
- molindone
- montelukast
- morphine
- morphine liposomal
- mosunetuzumab
- multivitamin, prenatal
N
- nabilone
- nalbuphine
- naltrexone
- nateglinide
- nelfinavir
- nevirapine
- nitazoxanide
- nitisinone
- nitrofurantoin
- nortriptyline
O
- olanzapine
- olopatadine nasal
- omaveloxolone
- omeprazole
- ondansetron
- opicapone
- opium
- orphenadrine
- ospemifene
- oxazepam
- oxcarbazepine
- oxtriphylline
- oxymorphone
P
- paclitaxel
- paclitaxel protein-bound
- pancuronium
- paraldehyde
- paricalcitol
- paroxetine
- pazopanib
- pegaspargase
- peginterferon beta-1a
- pemoline
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perphenazine
- phenelzine
- phenindamine
- phenobarbital
- phensuximide
- pimavanserin
- pimozide
- pioglitazone
- pipecuronium
- pirfenidone
- pomalidomide
- ponatinib
- ponesimod
- pramipexole
- pramlintide
- prednisolone
- prednisone
- pregabalin
- primidone
- procaine
- prochlorperazine
- procyclidine
- progesterone
- progesterone topical
- promazine
- promethazine
- proparacaine ophthalmic
- propiomazine
- protriptyline
- pyridoxine
- pyrilamine
Q
R
- rabies immune globulin, human
- ramelteon
- ranitidine
- ranitidine bismuth citrate
- rapacuronium
- rasagiline
- regorafenib
- remdesivir
- remifentanil
- remimazolam
- repaglinide
- respiratory syncytial virus immune globulin
- rho (d) immune globulin
- rifabutin
- rifapentine
- rilonacept
- riociguat
- ritlecitinib
- ritonavir
- rocuronium
- roflumilast
- romidepsin
- ropeginterferon alfa-2b
- ropinirole
- ropivacaine
- rosiglitazone
- rotigotine
- rucaparib
- rufinamide
- ruxolitinib
S
- safinamide
- saquinavir
- sarilumab
- satralizumab
- saxagliptin
- scopolamine
- secobarbital
- secukinumab
- selegiline
- selexipag
- selinexor
- semaglutide
- sertraline
- sibutramine
- silodosin
- siltuximab
- silver nitrate topical
- silver sulfadiazine topical
- sitagliptin
- sodium bicarbonate
- sodium citrate
- solifenacin
- sotagliflozin
- st. john's wort
- succinylcholine
- sucralfate
- sufentanil
- sulfadiazine
- sulfadoxine
- sulfamethizole
- sulfasalazine
- sulfinpyrazone
- sulfisoxazole
T
- tadalafil
- talquetamab
- tamoxifen
- tapentadol
- tarlatamab
- tebentafusp
- teclistamab
- temazepam
- teniposide
- tetanus immune globulin
- tetrabenazine
- tetracaine
- tetracaine ophthalmic
- tetracaine topical
- thalidomide
- thallous chloride, tl-201
- theophylline
- thiethylperazine
- thioguanine
- thioridazine
- thiotepa
- thiothixene
- thyroid desiccated
- tiagabine
- ticlopidine
- tinidazole
- tipranavir
- tirzepatide
- tizanidine
- tocilizumab
- tolazamide
- tolbutamide
- tolcapone
- topiramate
- tramadol
- tranylcypromine
- trazodone
- treprostinil
- triamcinolone
- triazolam
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- troglitazone
- troleandomycin
- tubocurarine
U
V
- vaccinia immune globulin
- valdecoxib
- valerian
- valoctocogene roxaparvovec
- valproic acid
- vandetanib
- varicella zoster immune globulin
- vecuronium
- venlafaxine
- vilazodone
- vinblastine
- vincristine
- vincristine liposome
- vinorelbine
- vortioxetine
W
Z
Phenytoin alcohol/food interactions
There is 1 alcohol/food interaction with phenytoin.
Phenytoin disease interactions
There are 12 disease interactions with phenytoin which include:
- blood dyscrasias
- liver disease
- porphyria
- renal dysfunction
- cardiotoxicity
- suicidal tendency
- arrhythmias
- hyperglycemia
- megaloblastic anemia
- osteomalacia
- alcoholism
- thyroid function tests
More about phenytoin
- phenytoin consumer information
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (112)
- Drug images
- Latest FDA alerts (3)
- Side effects
- Dosage information
- During pregnancy
- Drug class: group I antiarrhythmics
- Breastfeeding
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.