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Phenylephrine / scopolamine ophthalmic Drug Interactions

A total of 300 drugs are known to interact with phenylephrine / scopolamine ophthalmic.

  • 10 major drug interactions
  • 290 moderate drug interactions

Check for interactions with phenylephrine / scopolamine ophthalmic

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Medications known to interact with phenylephrine / scopolamine ophthalmic


  • acebutolol (Sectral)
  • acetaminophen / caffeine / chlorpheniramine / hydrocodone / phenylephrine (Hycomine Compound)
  • acetaminophen / caffeine / guaifenesin / phenylephrine (Emagrin Forte (old formulation))
  • acetaminophen / chlorpheniramine / codeine / phenylephrine (Colrex Compound, Colrex)
  • acetaminophen / chlorpheniramine / dextromethorphan / guaifenesin / phenylephrine (Tylenol Cold and Flu Severe Day & Night)
  • acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine (Codral Cold and Flu + Cough Day and Night, XL-3 Xtra Cold and Cough, Dimetapp Children's Multi-Symptom Cold & Flu (old formulation), Tylenol Children’s Cold + Flu, PediaCare Multi-Symptom Cold Plus Acetaminophen, Alka-Seltzer Plus Cold & Cough Formula Liquid, PediaCare Flu Plus Acetaminophen, Tylenol Cold Multi-Symptom Nighttime, Tylenol Cold Head Congestion Nighttime, Comtrex Cold & Cough Day Night, Theraflu Nighttime Severe Cold & Cough Caplets, Tylenol Cold Head Congestion Day and Night, Comtrex Nighttime Cold & Cough, Cold Multi-Symptom (Nighttime), Multi Symptom Cold (Night Formula), Multi Symptom Cold Relief, Alka-Seltzer Plus Maximum Strength Cold & Cough Liquid Gels, Alka-Seltzer Plus Severe Cold & Flu Formula Effervescent Tablets, Alka-Seltzer Plus Flu Formula, Alka-Seltzer Plus Severe Sinus & Cold Hot Drink Mix, Dimetapp Children's Nighttime Flu, Theraflu Warming Relief Nighttime Multi-Symptom Cold Caplets, Triaminic Multi-Symptom Fever & Cold)
  • acetaminophen / chlorpheniramine / phenylephrine (Alka-Seltzer Plus Cold, Norel AD, XL-3 Cold Medicine, Dristan Cold Multi Symptom Formula, Contac Cold + Flu (Night Formula), Medicidin-D, ConRx Allergy Sinus, Allergy Pain Relief, Allergy Sinus PE Pain Relief, PX Allergy Sinus PE, Allergy Multi-Symptom, Pyrroxate, Robitussin Peak Cold Nighttime Nasal Relief, Relief-PE, Onset Forte, GNP Cold Relief Plus, Super Strength Sinadrin, Gendecon, Tylenol Allergy Multi-Symptom, Tylenol Sinus Congestion & Pain Nighttime, Comtrex Severe Cold & Sinus, Comtrex Flu Therapy, Tylenol Plus Children's Cold, Protid, Hybrid CF, Sine-Off Sinus/Cold, Tylenol Sinus Congestion and Pain Cool Burst Day Night, Alka-Seltzer Plus Cold & Flu, HEB Allergy, Dryphen)
  • acetaminophen / chlorpheniramine / phenylephrine / phenylpropanolamine / pyrilamine (Covangesic)
  • acetaminophen / chlorpheniramine / phenylephrine / phenyltoloxamine (Norel SR, Trital SR)
  • acetaminophen / chlorpheniramine / phenylephrine / salicylamide (Rhinogesic)
  • acetaminophen / codeine / guaifenesin / phenylephrine (Phenflu CDX, Phenflu CD)
  • acetaminophen / dextromethorphan / diphenhydramine / phenylephrine (Respa C&C, Respa C&C IR)
  • acetaminophen / dextromethorphan / doxylamine / guaifenesin / phenylephrine (Mucinex Fast-Max Day & Night, Mucinex Sinus-Max Day & Night)
  • acetaminophen / dextromethorphan / doxylamine / phenylephrine (Vicks NyQuil Severe Cold & Flu, Delsym Night Time Multi-Symptom, Tylenol Cold Multi-Symptom Nighttime Liquid, Alka-Seltzer Plus Night Cold Formula Liquid, Alka-Seltzer Plus Multi-Symptom Cold & Flu (Night Formula), Alka-Seltzer Plus Severe Sinus Congestion & Cough (Night Formula), Mucinex Fast-Max Night Time Cold & Flu Liquid Gels, Alka-Seltzer Plus Severe Sinus Congestion, Allergy & Cough Liquid Gels, Alka-Seltzer Plus Maximum Strength Night Cold & Flu Liquid Gels, Alka-Seltzer Plus Maximum Strength Day & Night Cold & Flu Liquid Gels (Night Formula), Alka-Seltzer Plus Multi-Symptom Cold & Flu Day & Night Liquid Gels (Night Formula), Alka-Seltzer Plus Night Severe Cold+Flu Hot Drink Mix)
  • acetaminophen / dextromethorphan / guaifenesin / phenylephrine (Vicks DayQuil Severe Cold & Flu, Cough & Cold Relief, Tylenol Cold & Flu Severe, Mucinex Children's Cold, Cough & Sore Throat, Mucinex Fast-Max Day Time Severe Cold, Sudafed PE Cold & Cough, Mucinex Fast-Max Cold, Flu & Sore Throat Liquid Gels, Mucinex Fast-Max Cold, Flu & Sore Throat, Mucinex Fast-Max Severe Congestion & Cold, Decorel Forte Plus, Mucinex Children's Multi-Symptom Cold & Fever, Delsym Cough+ Cold Day Time, Mucinex Fast-Max Severe Cold, Tylenol Cold Multi-Symptom Severe, Non-Pseudo Cold Relief, CounterAct Day, Tylenol Cold Head Congestion Severe (old formulation), Alka-Seltzer Plus Severe Cough, Mucus & Congestion Liquid Gels, Alka-Seltzer Plus Severe Sinus, Cold & Cough Liquid Gels, Phenflu DM, Alka-Seltzer Plus Severe Cold, Mucus & Congestion, Alka-Seltzer Plus Day Severe Cold+Flu Hot Drink Mix, Cold Head Congestion, Cold Multi-Symptom Severe, ConRx Cold, Robitussin Severe Multi-Symptom Cough Cold + Flu, Adult Cold, Flu & Sore Throat, Mucus Relief Complete, Mucus Relief Plus, Cold & Cough PE Multi-Symptom, Suphedrine PE Cold & Cough, Sudafed PE Pressure+Pain+Cold, Tylenol Cough & Severe Congestion Daytime)
  • acetaminophen / dextromethorphan / phenylephrine (Vicks Dayquil Cold & Flu Relief, Daytime Cold & Flu, Neocitran Non Drowsy Extra Strength Cold and Flu, Comtrex Cold & Cough, Vicks Dayquil Cold & Flu Symptom Relief Plus Vitamin C, Multi Symptom Cold (Day Formula), Robitussin Peak Cold Daytime Cold + Flu, Contac Complete Cough, Cold & Flu Extra Strength, Tylenol Plus Children's Cold & Cough, Robitussin Cold + Flu (Daytime), Mapap Cold Formula, Little Colds Multi-Symptom, Vicks Nature Fusion Cold & Flu Multi-Symptom Relief, Theraflu Daytime Severe Cold & Cough, Comtrex Cold and Cough Maximum Strength, Day Relief PE, Day Time Multi-Symptom Cold/Flu Relief, Alka-Seltzer Plus Severe Sinus Congestion & Cough Liquid Gels, Alka-Seltzer Plus Maximum Strength Day Cold & Flu Liquid Gels, Alka-Seltzer Plus Maximum Strength Day & Night Cold & Flu Liquid Gels (Day Formula), Alka-Seltzer Plus Severe Sinus Congestion & Cough (Day Formula), Alka-Seltzer Plus Multi-Symptom Cold & Flu Day Liquid Gels, Theraflu Multi-Symptom Severe Cold with Lipton Flavors, Cold Multi-Symptom (Daytime), Theraflu Warming Relief Daytime Multi-Symptom Cold Caplets, Theraflu Warming Relief Daytime Severe Cold & Cough, Tylenol Cold Max Day, Tylenol Cold Head Congestion Daytime, Sudafed PE Pressure+Pain+Cough, Flu & Severe Cold & Cough Daytime Powder, Theraflu ExpressMax Daytime Severe Cold & Cough)
  • acetaminophen / diphenhydramine / phenylephrine (Theraflu Nighttime Severe Cold & Cough, CVS Allergy & Cold, Robitussin Severe Multi-Symptom Cough Cold + Flu Nighttime, Mucinex Sinus-Max Night Time Congestion & Cough, Mucinex Fast-Max Night Time Cold & Flu, Severe Allergy and Sinus Headache, Benadryl Allergy Plus Cold, Dimetapp Children's Multi-Symptom Cold & Flu, Tylenol Plus Children's Cold & Allergy, Sudafed PE Severe Cold, Theraflu Warming Relief Nighttime Severe Cold & Cough, Delsym Cough+ Cold Night Time, Delsym Children’s Cough+ Cold Night Time, Night Time Severe Cold and Cough, Suphedrine PE Severe Cold, CounterAct Night, Robitussin Multi-Symptom Cold Night Time, Mucinex Children's Night Time Multi-Symptom Cold, Mucinex Sinus-Max Day & Night (Night), Sudafed PE Nighttime Cold, Theraflu Warming Relief Flu & Sore Throat, Benadryl Severe Allergy Plus Sinus Headache, Equate Allergy & Sinus Headache, Tylenol Allergy Multi-Symptom Nighttime, CVS Allergy & Sinus Headache, Children's Tylenol Plus Cold And Allergy, Theraflu Warming Relief Sinus & Cold, Theraflu ExpressMax Nighttime Severe Cold & Cough, Theraflu ExpressMax Flu, Cough & Sore Throat, Theraflu Nighttime Multi-Symptom Severe Cold With Lipton Flavors, Benadryl Allergy Plus Sinus Headache)
  • acetaminophen / doxylamine / phenylephrine (Vicks QlearQuil Nighttime Sinus & Congestion, Alka-Seltzer Plus Severe Allergy Sinus Congestion & Headache, Vicks Sinex Nighttime)
  • acetaminophen / guaifenesin / phenylephrine (Sinus Congestion & Pain, Mucinex Sinus-Max Severe Congestion Relief, Mucinex Sinus-Max Day & Night (Day), Tylenol Sinus Severe Day, Sudafed PE Pressure+Pain+Mucus, Beechams All-in-One, Duratuss-A, LuSonex Plus, Mucinex Fast-Max Cold & Sinus, Mucinex Sinus-Max Pressure & Pain, ConRx Sinus, Histenol-Forte II, Theraflu Warming Relief Cold and Chest Congestion, Emagrin Forte, Tylenol Cold Head Congestion Severe, Sudafed PE Triple Action, Coldonyl, Mucinex Sinus-Max Day Time Severe Congestion Relief)
  • acetaminophen / pheniramine / phenylephrine (Theraflu Cold & Sore Throat, Theraflu Flu & Sore Throat, Scot-Tussin Original, Theraflu Sinus & Cold)
  • acetaminophen / phenylephrine (Sudafed PE Pressure + Pain, Tylenol Sinus + Headache Day, Vicks Sinex Daytime, Non-Pseudo Sinus Pain & Pressure, Contac Cold + Flu (Day Formula), Sinus Congestion and Pain Daytime Cool Ice, Tylenol Plus Children's Cold & Stuffy Nose, Suphedrine PE Sinus Headache, Vicks QlearQuil Daytime Sinus & Congestion, Robitussin Peak Cold Nasal Relief, Excedrin Sinus Headache, Dilotab II, D-Time Sinus, Day Relief Sinus PE, Congespirin Aspirin Free, Alka-Seltzer Plus Cold and Sinus, Mapap Sinus Congestion and Pain, Sinutab Sinus Maximum Strength)
  • acetylcholine ophthalmic (Miochol, Miochol-E, Miochol Plus, Miochol-E/Steri-Tags, Miochol-E System Pak)
  • albuterol (Ventolin, ProAir HFA, Ventolin HFA, Proventil, Proventil HFA, ProAir RespiClick, Respirol, AccuNeb, Vospire ER, Airet, Volmax, ProAir Digihaler)
  • albuterol / ipratropium (DuoNeb, Combivent, Combivent Respimat)
  • ammonium chloride / chlorpheniramine / codeine / phenylephrine (Rolatuss)
  • ammonium chloride / chlorpheniramine / dextromethorphan / ephedrine / ipecac / phenylephrine (Quelidrine)
  • amylase / cellulase / hyoscyamine / lipase / phenyltoloxamine / protease (Gastrinex, Digex)
  • anhydrous calcium iodide / isoproterenol (Norisodrine with Calcium Iodine)
  • arformoterol (Brovana)
  • aspirin / caffeine / orphenadrine (Norgesic, Norgesic Forte, Orphengesic Forte, Orphengesic)
  • aspirin / chlorpheniramine / phenylephrine (Alka-Seltzer Plus Cold Formula Sparkling Original Effervescent Tablets, Alka-Seltzer Plus Cold Formula Cherry Burst Effervescent Tablets, Alka-Seltzer Plus Cold Formula Orange Zest Effervescent Tablets)
  • atenolol (Tenormin)
  • atenolol / chlorthalidone (Tenoretic, Tenoretic 50, Tenoretic 100)
  • atropine (AtroPen, Sal-Tropine, Atreza)
  • atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine (Atrohist Plus, Deconhist LA, Rolatuss-SR, Protuss Tablet, Ex-Tuss)
  • atropine / chlorpheniramine / hyoscyamine / phenylephrine / scopolamine (AccuHist LA, Bellahist-D LA, Histacol LA)
  • atropine / chlorpheniramine / hyoscyamine / pseudoephedrine / scopolamine (Stahist, Ru-Tuss, Respa-AR)
  • atropine / difenoxin (Motofen)
  • atropine / diphenoxylate (Lomotil, Lomocot, Logen, Lomanate, Vi-Atro, Lonox)
  • atropine / edrophonium (Enlon-Plus)
  • atropine / hyoscyamine / phenobarbital / scopolamine (Donnatal, Antispasmodic, Donnatal Extentabs, Phenohytro, Spasmolin, Vitetal, Hyosophen, Elixiral, Haponal, Servira, Antispas, B-Donna Tablets, Chardonna-2, Donnapine, Bellatal, Barbidonna, Bellalphen, D-Tal, Donnaphen, Spasquid, Alkabel-SR, Bellatal ER, Me-PB-Hyos, Quadrapax, Se-Donna PB HYOS, RE-PB Hyos Elixir, Kinesed, PB-Hyos)
  • atropine / phenobarbital (Antrocol)
  • atropine / pralidoxime (ATNAA, DuoDote)
  • galantamine (Razadyne, Razadyne ER, Reminyl)
  • glycopyrrolate (Robinul, Lonhala Magnair, Seebri Neohaler, Cuvposa, Robinul Forte, Glycate, Glyrx-PF)
  • glycopyrrolate / indacaterol (Utibron Neohaler)
  • guaifenesin / hydrocodone / pheniramine / phenylephrine / phenylpropanolamine (S-T Forte)
  • guaifenesin / hydrocodone / phenylephrine (Mintuss G, Atuss G, Ambi 5/15/100, Tussafed-HC, Levall 5.0, Hydro GP, De-Chlor G, Dynatuss HC, Tussafed-HCG, Uni-Lev 5.0, Crantex HC, Duratuss HD, Simuc-HD, Gentex HC, Donatussin DC, Guiaplex HC, Exetuss-HC, Qual-Tussin DC, Nariz HC, MonteFlu HC, Nazarin HC, HydroFed)
  • guaifenesin / phenylephrine (Deconex, Gilphex TR, Reluri, Refenesen Chest Congestion Relief PE, Mucus Relief Sinus, Pendex, Nasex, Rescon-GG, Chest Congestion Relief PE, Efasin, Wellbid-D, Xpect-PE, Guaiphen-D 600, Guaiphen-D 1200, Donatussin Drops, Simuc, Zotex GPX, Duomax, Guaifen PE, Norel EX, Aldex G, Nexphen PD, Nariz, Duraphen 1000, Lusonex, Dynex LA, Miraphen PE, Sudex, Extendryl G, Maxiphen, Entex LA, Guaphenyl LA, MontePhen, Gentex LA, Xedec II, Liquibid-D, Simuc-GP, Zotex-GP, Triaminic Chest & Nasal Congestion, Duratuss PE, Sitrex PD, Mydex, Medent-PE, Genexa LA, Nazarin, Ambi 40/1000, J-Max, Medent-PEI, D-Phen 1000, Mucinex Children's Stuffy Nose & Cold, Visonex, Deconex IR, Guiadex PD, Guiatex PE, Entex LQ, Aquatab D, Respa-PE, Sudafed PE Non-Drying Sinus, Liquibid D-R, Liquibid PD-R, Relcof IR, Lusair, D-Tab, ExeTuss, ExeTuss-GP, MucaphEd, Fenesin PE IR, Reese Onetab Congestion & Cough, Nu-COPD, Supress-PE, Dimetapp Children's Cold & Chest Congestion, Zyrphen, PE-Guai, Tussi-Pres PE, Sinupan, Deconsal Pediatric, Mucus Relief PE, Amidal, Chemdal, Quindal, Endal, Prolex D, SINUvent PE, Crantex, Crantex LA Capsules, Amitex LA, Entex ER, Duraphen II, Liquibid-PD, Crantex ER, Liquibid-D 1200, Phenavent LA, Quintex, Phenavent D, Deconsal II, Guaifed Caps, Guaifed PD, Sina-12X, Phenavent, Tussbid, Phenavent PED, Nescon-PD, Prolex PD, Aldex, Duravent PE, Crantex LA Tablets, ED Bron GP, Duratuss, Duratuss GP, Sitrex, Guaiphen-PD, Wellbid-D 1200, Despec, Xedec, Nasex-G)
  • guaifenesin / phenylephrine / phenylpropanolamine (Guaifenex, Norel, Altex Liquid, Cyntex Liquid, Fentex, Guiatex, Ami-Tex, Duratex, Banex, Phenylfenesin, Dura-Gest, Equi-Tex, Phentex, Entac, Enomine, Coldloc)
  • guaifenesin / phenylephrine / pyrilamine (Ryna-12X, A-Tan 12X)
  • guanadrel (Hylorel)
  • guanethidine (Ismelin)
  • guanethidine / hydrochlorothiazide (Esimil)
  • olodaterol (Striverdi Respimat)
  • olodaterol / tiotropium (Stiolto Respimat)
  • orphenadrine (Norflex, Norflex Injectable, Flexon, Myolin, Orphenate, Flexoject, Banflex, Mio-Rel, Orfro, Antiflex)
  • oxybutynin (Ditropan, Ditropan XL, Oxytrol, Anturol, Gelnique, Urotrol, Oxytrol for Women)

Phenylephrine / scopolamine ophthalmic disease interactions

There are 5 disease interactions with phenylephrine / scopolamine ophthalmic which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.