Can you take Perampanel with Phlemex?
1 drug interaction and 8 additional warnings found for the following 2 drugs:
- perampanel
- Phlemex (dextromethorphan/guaifenesin)
Drug interactions
Moderate drug interactions
Moderate:
dextromethorphan perampanel
Applies to: Phlemex (dextromethorphan / guaifenesin) and perampanel
Using dextromethorphan together with perampanel may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
dextromethorphan Food/Lifestyle
Applies to: Phlemex (dextromethorphan / guaifenesin)
Alcohol can increase the nervous system side effects of dextromethorphan such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with dextromethorphan. Do not use more than the recommended dose of dextromethorphan, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
Moderate:
perampanel Food/Lifestyle
Applies to: perampanel
Alcohol can increase the nervous system side effects of perampanel such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with perampanel. Do not use more than the recommended dose of perampanel, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
Disease interactions
6 potential interactions Applies to: 6 conditions, including High Cholesterol, Depression, Weight Loss, Psychosis, and Liver Disease.
Depression
Moderate:
perampanel
Perampanel has a moderate potential interaction with Depression.
Antiepileptic drugs (AEDs) have been associated with an increased risk of suicidal thoughts or behavior in patients taking these drugs for any indication. Pooled analyses of 199 placebo-controlled clinical studies involving the use of 11 different AEDs showed that patients receiving AEDs had approximately twice the risk of suicidal thinking or behavior compared to patients receiving placebo. AEDs should be administered cautiously in patients with depression or other psychiatric disorders; phentermine-topiramate should be avoided in patients with history of suicidal attempts or active suicidal ideation. The risk of suicidal thoughts and behavior should be carefully assessed against the risk of untreated illness, bearing in mind that epilepsy and many other conditions for which AEDs are prescribed are themselves associated with morbidity and mortality and an increased risk of suicidal thoughts and behavior. Patients, caregivers, and families should be alert to the emergence or worsening of signs and symptoms of depression, any unusual changes in mood or behavior, or the emergence of suicidal thoughts or behavior. If patients have symptoms of suicidal ideation or behavior, a dosage reduction or treatment discontinuation should be considered.
High Cholesterol
Moderate:
perampanel
Perampanel has a moderate potential interaction with High Cholesterol.
Increased levels of triglycerides have occurred in patients using perampanel. Care should be taken when prescribing this agent to patients with high triglycerides levels, and close monitoring of lipid profile is recommended during therapy.
Liver Disease
Moderate:
perampanel
Perampanel has a moderate potential interaction with Liver Disease.
The use of perampanel in patients with severe hepatic impairment is not recommended. Dosage adjustments are recommended in patients with mild or moderate hepatic impairment as the half-life of perampanel may increase in these patients. Care should be exercised when prescribing this agent to patients with hepatic impairment, and close monitoring of liver function is recommended.
Psychosis
Moderate:
perampanel
Perampanel has a moderate potential interaction with Psychosis.
Antiepileptic drugs (AEDs) have been associated with an increased risk of suicidal thoughts or behavior in patients taking these drugs for any indication. Pooled analyses of 199 placebo-controlled clinical studies involving the use of 11 different AEDs showed that patients receiving AEDs had approximately twice the risk of suicidal thinking or behavior compared to patients receiving placebo. AEDs should be administered cautiously in patients with depression or other psychiatric disorders; phentermine-topiramate should be avoided in patients with history of suicidal attempts or active suicidal ideation. The risk of suicidal thoughts and behavior should be carefully assessed against the risk of untreated illness, bearing in mind that epilepsy and many other conditions for which AEDs are prescribed are themselves associated with morbidity and mortality and an increased risk of suicidal thoughts and behavior. Patients, caregivers, and families should be alert to the emergence or worsening of signs and symptoms of depression, any unusual changes in mood or behavior, or the emergence of suicidal thoughts or behavior. If patients have symptoms of suicidal ideation or behavior, a dosage reduction or treatment discontinuation should be considered.
Renal Dysfunction
Major:
perampanel
Perampanel has a major potential interaction with Renal Dysfunction.
Perampanel should be used with caution in patients with moderate renal impairment, and slower titration may be considered. No dose adjustment is required in patients with mild renal impairment. Care should be taken when prescribing this agent in patients with renal impairment, and close monitoring of renal function is recommended. The use of perampanel in patients with severe renal impairment or patients undergoing hemodialysis is not recommended.
Weight Loss
Moderate:
perampanel
Perampanel has a moderate potential interaction with Weight Loss.
Weight gain has occurred with the use of perampanel. Care should be taken when prescribing this agent to patients predisposed to weight gain, and regular monitoring of weight is recommended.
Report options
More resources
perampanel
A total of 342 drugs are known to interact with perampanel.
- Perampanel is in the drug class AMPA receptor antagonists.
- Perampanel is used to treat the following conditions:
Phlemex
A total of 375 drugs are known to interact with Phlemex.
- Phlemex is in the drug class upper respiratory combinations.
- Phlemex is used to treat the following conditions:
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.