Drug Interactions between Novasal and tacrolimus
This report displays the potential drug interactions for the following 2 drugs:
- Novasal (magnesium salicylate)
- tacrolimus
Interactions between your drugs
No interactions were found between Novasal and tacrolimus. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Novasal
A total of 279 drugs are known to interact with Novasal.
- Novasal is in the drug class salicylates.
- Novasal is used to treat the following conditions:
tacrolimus
A total of 835 drugs are known to interact with tacrolimus.
- Tacrolimus is in the drug class calcineurin inhibitors.
-
Tacrolimus is used to treat the following conditions:
- Crohn's Disease (off-label)
- Graft-versus-host disease (off-label)
- Nephrotic Syndrome (off-label)
- Organ Transplant, Rejection Prophylaxis
- Organ Transplant, Rejection Reversal
Drug and food interactions
tacrolimus food
Applies to: tacrolimus
ADJUST DOSING INTERVAL: Consumption of food has led to a 27% decrease in the bioavailability of orally administered tacrolimus.
MANAGEMENT: Tacrolimus should be administered at least one hour before or two hours after meals.
GENERALLY AVOID: Grapefruit juice has been reported to increase tacrolimus trough concentrations. Data are limited, but inhibition of the CYP450 enzyme system appears to be involved.
MANAGEMENT: The clinician may want to recommend that the patient avoid ingesting large amounts of grapefruit juice while taking tacrolimus.
References
- (2001) "Product Information. Prograf (tacrolimus)." Fujisawa
- Hooks MA (1994) "Tacrolimus, a new immunosuppressant--a review of the literature." Ann Pharmacother, 28, p. 501-11
magnesium salicylate food
Applies to: Novasal (magnesium salicylate)
GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.
MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.
References
- (2002) "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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