Can You Take Nolvadex with Polyethylene glycol 3350 with electrolytes?
This report displays the potential drug interactions for the following 2 drugs:
- Nolvadex (tamoxifen)
- polyethylene glycol 3350 with electrolytes
Interactions between your drugs
tamoxifen polyethylene glycol 3350 with electrolytes
Applies to: Nolvadex (tamoxifen) and polyethylene glycol 3350 with electrolytes
Tamoxifen can cause an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. The risk is increased if you have low blood levels of magnesium or potassium, which can occur with bowel cleansing preparations or excessive use of medications that have a laxative effect. You should use polyethylene glycol 3350 with electrolytes exactly as prescribed by your doctor, and drink plenty of clear liquids before, during, and after the cleansing process to avoid becoming dehydrated. Your doctor may be able to recommend specific fluids you can drink before starting polyethylene glycol 3350 with electrolytes to help maintain your electrolyte levels. He/she may also want to monitor your electrolyte levels and/or heart rhythm. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications. In addition, you should let your doctor know if you experience signs and symptoms of low electrolyte levels such as weakness, tiredness, drowsiness, dizziness, confusion, tingling, numbness, muscle pain, cramps, nausea, or vomiting. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug and food/lifestyle interactions
tamoxifen food/lifestyle
Applies to: Nolvadex (tamoxifen)
Talk to your doctor before using tamoxifen with soy products. There is some evidence that substances present in soy may stimulate breast tumor growth and interfere with the action of tamoxifen, although this has not been proven. Whether soy products are effective for hot flashes is also uncertain. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
polyethylene glycol 3350 with electrolytes food/lifestyle
Applies to: polyethylene glycol 3350 with electrolytes
Mixing polyethylene glycol 3350 with electrolytes and starch-based food thickeners can reduce the thickening effect, which could increase the chance of the liquid going down the wrong way (aspiration), especially if you have trouble swallowing. Also, taking oral medications within one hour of starting polyethylene glycol 3350 with electrolytes may speed up movement through your digestive system, potentially reducing the absorption and effectiveness of those medications. Try to avoid taking other oral medications during and within one hour after starting polyethylene glycol 3350 with electrolytes. It's important to inform your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor
Disease interactions
polyethylene glycol 3350 with electrolytes Gastrointestinal Obstruction
Applies to: Gastrointestinal Obstruction
The use of laxatives is contraindicated in patients with intestinal obstruction disorders. Patients with intestinal obstruction disorders may need their underlying condition treated to correct the constipation. Some laxatives require reduction in the colon to their active form to be effective which may be a problem in patients with intestinal obstruction.
polyethylene glycol 3350 with electrolytes Gastrointestinal Obstruction
Applies to: Gastrointestinal Obstruction
The use of polyethylene glycol (PEG) solutions is contraindicated in patients with gastrointestinal obstruction, perforation, or toxic megacolon. If gastrointestinal obstruction or perforation is suspected, appropriate studies should be performed prior to administration of these agents. Use with caution in patients with severe active ulcerative colitis. Increased activity of the gut caused by these agents could worsen these conditions.
polyethylene glycol 3350 with electrolytes Gastrointestinal Perforation
Applies to: Gastrointestinal Perforation
The use of polyethylene glycol (PEG) solutions is contraindicated in patients with gastrointestinal obstruction, perforation, or toxic megacolon. If gastrointestinal obstruction or perforation is suspected, appropriate studies should be performed prior to administration of these agents. Use with caution in patients with severe active ulcerative colitis. Increased activity of the gut caused by these agents could worsen these conditions.
polyethylene glycol 3350 with electrolytes Inflammatory Bowel Disease
Applies to: Inflammatory Bowel Disease
The use of laxatives is contraindicated in patients with inflammatory bowel disease. Patients with inflammatory bowel disease may experience colonic perforation with use of stimulant laxatives.
tamoxifen Thrombotic/Thromboembolic Disorder
Applies to: Thrombotic / Thromboembolic Disorder
The use of tamoxifen is contraindicated in women with a history of deep vein thrombosis or pulmonary embolus or in women who require concomitant coumarin- type anticoagulant therapy. There is evidence of an increased incidence of thromboembolic events, including deep vein thrombosis and pulmonary embolism, during tamoxifen therapy.
polyethylene glycol 3350 with electrolytes Ulcerative Colitis
Applies to: Ulcerative Colitis
The use of polyethylene glycol (PEG) solutions is contraindicated in patients with gastrointestinal obstruction, perforation, or toxic megacolon. If gastrointestinal obstruction or perforation is suspected, appropriate studies should be performed prior to administration of these agents. Use with caution in patients with severe active ulcerative colitis. Increased activity of the gut caused by these agents could worsen these conditions.
tamoxifen Bleeding
Applies to: Bleeding
Hematological abnormalities during tamoxifen therapy may include thrombocytopenia, leukopenia, and anemia. Rare hemorrhagic episodes, severe neutropenia and pancytopenia have been reported. Therapy with tamoxifen should be administered cautiously to patients with or predisposed to bone marrow suppression.
tamoxifen Bone Marrow Depression/Low Blood Counts
Applies to: Bone Marrow Depression/Low Blood Counts
Hematological abnormalities during tamoxifen therapy may include thrombocytopenia, leukopenia, and anemia. Rare hemorrhagic episodes, severe neutropenia and pancytopenia have been reported. Therapy with tamoxifen should be administered cautiously to patients with or predisposed to bone marrow suppression.
polyethylene glycol 3350 with electrolytes Dehydration
Applies to: Dehydration
Use caution when prescribing PEG electrolyte solutions to patients with impaired renal function or patients taking concomitant medications that may affect renal function. Ensure adequate hydration and consider performing baseline and post-colonoscopy laboratory tests (electrolytes, creatinine, and BUN) in these patients.
tamoxifen Endometrial Dysplasia
Applies to: Endometrial Dysplasia
Endometrial changes such as hyperplasia, polyps, and endometrial cancer have been reported during tamoxifen therapy. Patients should be instructed to immediately report any signs or symptoms of uterine abnormality such as menstrual irregularities, abnormal vaginal bleeding, change in vaginal discharge, or pelvic pain or pressure. Therapy with tamoxifen should be administered cautiously in patients with or history of gynecological abnormalities.
polyethylene glycol 3350 with electrolytes Esophageal Obstruction
Applies to: Esophageal Obstruction
Patients with impaired gag reflex, unconscious or semi-conscious patients, and patients prone to regurgitation or aspiration should be administered polyethylene glycol (PEG) electrolyte solutions cautiously. Patients experiencing severe bloating, distention or abdominal pain may need to receive PEG electrolyte solutions at a slower rate.
polyethylene glycol 3350 with electrolytes Heart Disease
Applies to: Heart Disease
The use of ionic osmotic laxative products for bowel preparation has been associated with rare reports of serious arrhythmias. Use caution when prescribing PEG electrolyte solutions in patients at increased risk of arrhythmias (e.g., patients with a history of prolonged QT, uncontrolled arrhythmias, recent myocardial infarction, unstable angina, congestive heart failure, or cardiomyopathy). Clinical monitoring of cardiovascular status is recommended prior to, during, and after therapy.
polyethylene glycol 3350 with electrolytes Hyponatremia
Applies to: Hyponatremia
PEG electrolyte solutions have been associated with seizure activity, and/or loss of consciousness. The seizure cases were associated with electrolyte abnormalities and low serum osmolality. Therapy with these agents should be administered cautiously in patients with a history of or predisposition to seizures or in patients with known or suspected hyponatremia.
tamoxifen Liver Disease
Applies to: Liver Disease
Tamoxifen is extensively metabolized by the liver and excreted in the feces. Alteration in liver enzyme levels have been noted. Severe hepatic injuries such as fatty liver, cholestasis, hepatitis, and hepatic necrosis are rare, however, deaths have been reported. Patients should be instructed to immediately report any sign or symptoms of hepatic dysfunction such as jaundice, dark urine, right upper quadrant pain, or anorexia. Therapy with tamoxifen should be administered cautiously in patients with or predisposed to compromised hepatic function.
polyethylene glycol 3350 with electrolytes Renal Dysfunction
Applies to: Renal Dysfunction
Use caution when prescribing PEG electrolyte solutions to patients with impaired renal function or patients taking concomitant medications that may affect renal function. Ensure adequate hydration and consider performing baseline and post-colonoscopy laboratory tests (electrolytes, creatinine, and BUN) in these patients.
polyethylene glycol 3350 with electrolytes Seizures
Applies to: Seizures
PEG electrolyte solutions have been associated with seizure activity, and/or loss of consciousness. The seizure cases were associated with electrolyte abnormalities and low serum osmolality. Therapy with these agents should be administered cautiously in patients with a history of or predisposition to seizures or in patients with known or suspected hyponatremia.
tamoxifen Visual Defect/Disturbance
Applies to: Visual Defect / Disturbance
Corneal changes, cataracts, and retinopathy have been reported during tamoxifen therapy. Therapy with tamoxifen should be administered cautiously in patients with or predisposed to visual disturbances.
Nolvadex
A total of 475 drugs are known to interact with Nolvadex.
- Nolvadex is in the following drug classes: hormones/antineoplastics, selective estrogen receptor modulators.
- Nolvadex is used to treat the following conditions:
polyethylene glycol 3350 with electrolytes
A total of 416 drugs are known to interact with polyethylene glycol 3350 with electrolytes.
- Polyethylene glycol 3350 with electrolytes is in the drug class laxatives.
- Polyethylene glycol 3350 with electrolytes is used to treat the following conditions:
See also
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.