Can you take Neostigmine with Tears Again Hydrate?
1 drug interaction and 7 additional warnings found for the following 2 drugs:
- neostigmine
- Tears Again Hydrate (bilberry/evening primrose/flax)
Drug interactions
Minor drug interactions
Minor:
neostigmine evening primrose
Applies to: neostigmine and Tears Again Hydrate (bilberry / evening primrose / flax)
Some clinicians have suggested that evening primrose and borage oil, both of which contain the omega-6 fatty acid gamma linolenic acid (GLA), may lower the seizure threshold and increase the risk of seizures during co-administration with other epileptogenic agents. However, data regarding the effect of gamma linolenic acid on seizure threshold are conflicting and limited.
The information above is from our professional interaction data. Consumer information is not available for this interaction.
Food/lifestyle interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease interactions
7 potential interactions Applies to: 7 conditions, including Arrhythmia, Hyperthyroidism, Liver Disease, Parkinsonism, and Ischemic Heart Disease.
Arrhythmia
Major:
neostigmine
Neostigmine has a major potential interaction with Arrhythmia.
Due to their pharmacological action, cholinesterase inhibitors can have a vagotonic effect on the sinoatrial and atrioventricular nodes producing bradycardia or heart block. Therapy with cholinesterase inhibitors should be administered cautiously in patients with preexisting bradycardia or underlying cardiac conduction abnormalities. Syncopal episodes have been reported. Atropine may be used to reverse bradycardia produced by cholinesterase inhibitors.
Hyperthyroidism
Moderate:
neostigmine
Neostigmine has a moderate potential interaction with Hyperthyroidism.
Many of the manifestations of hyperthyroidism may be exacerbated by increased levels of acetylcholine produced by cholinesterase inhibitors. Therapy with cholinesterase inhibitors should be administered cautiously to patients with hyperthyroidism. Monitoring of thyroid levels is recommended.
Intestinal Obstruction
Major:
neostigmine
Neostigmine has a major potential interaction with Intestinal Obstruction.
Neostigmine is contraindicated in mechanical obstruction of the urinary or intestinal tract and peritonitis.
Ischemic Heart Disease
Major:
neostigmine
Neostigmine has a major potential interaction with Ischemic Heart Disease.
The use of cholinesterase inhibitors has been associated with a constriction of coronary arteries. Therapy with cholinesterase inhibitors should be administered cautiously in patients with coronary artery disease.
Liver Disease
Moderate:
neostigmine
Neostigmine has a moderate potential interaction with Liver Disease.
Neostigmine is metabolized by microsomal enzymes in the liver, and the effect of hepatic impairment on pharmacokinetics has not been evaluated. Patients should be carefully monitored if hepatically cleared neuromuscular blocking agents are used, as their duration of action may be prolonged due to hepatic insufficiency.
Parkinsonism
Major:
neostigmine
Neostigmine has a major potential interaction with Parkinsonism.
Cholinesterase inhibitors should be used with caution in patients with parkinsonism. Some of these drugs might be contraindicated in these patients (refer to specific prescribing information). Symptoms of Parkinson's disease may be exacerbated with the increase in cholinergic activity. Caregivers and patients should be advised.
Urinary Tract Obstruction
Major:
neostigmine
Neostigmine has a major potential interaction with Urinary Tract Obstruction.
Neostigmine is contraindicated in mechanical obstruction of the urinary or intestinal tract and peritonitis.
Report options
More resources
neostigmine
A total of 139 drugs are known to interact with neostigmine.
- Neostigmine is in the following drug classes: cholinergic muscle stimulants, miscellaneous genitourinary tract agents.
- Neostigmine is used to treat the following conditions:
Tears Again Hydrate
A total of 263 drugs are known to interact with Tears Again Hydrate.
- Tears again hydrate is in the drug class herbal products.
- Tears again hydrate is used to treat Herbal Supplementation.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.