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Drug Interactions between milk thistle and Olysio

This report displays the potential drug interactions for the following 2 drugs:

  • milk thistle
  • Olysio (simeprevir)

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Interactions between your drugs


milk thistle simeprevir

Applies to: milk thistle and Olysio (simeprevir)

Using simeprevir together with milk thistle is not recommended. Products containing milk thistle may increase the blood levels of simeprevir. This may increase the risk of serious side effects such as skin rash and skin reactions to sunlight (photosensitivity), which may be severe enough to require hospitalization. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions


simeprevir food

Applies to: Olysio (simeprevir)

Food significantly increases the absorption of simeprevir. You should take each dose of simeprevir with food. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.