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Drug Interactions between irinotecan and sacituzumab govitecan

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

irinotecan sacituzumab govitecan

Applies to: irinotecan and sacituzumab govitecan

GENERALLY AVOID: Coadministration of sacituzumab govitecan with irinotecan may increase the risk of adverse effects, such as severe neutropenia, nausea, vomiting, and diarrhea. The proposed mechanism involves increased exposure to SN-38, a potent topoisomerase I inhibitor. SN-38 is the pharmacologically active metabolite of irinotecan, and considered to be approximately 1000 times more potent than irinotecan. However, SN-38 is also delivered to Trop-2-expressing cancer cells via the Trop-2-directed antibody drug conjugate sacituzumab govitecan-hziy. SN-38 is covalently attached to sacituzumab govitecan, which binds to Trop-2-expressing cancer cells and allows for internalization of SN-38 into these cells to interact with topoisomerase I.

MANAGEMENT: Sacituzumab govitecan should not be substituted for or used with other drugs containing irinotecan or the active metabolite SN-38.

References (2)
  1. Cerner Multum, Inc. "Australian Product Information."
  2. (2020) "Product Information. Trodelvy (sacituzumab govitecan)." Immunomedics

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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