Can you take Iophen DM NR with Memantine?
1 drug interaction and 5 additional warnings found for the following 2 drugs:
- Iophen DM NR (dextromethorphan/guaifenesin)
- memantine
Drug interactions
Moderate drug interactions
Moderate:
dextromethorphan memantine
Applies to: Iophen DM NR (dextromethorphan / guaifenesin) and memantine
Using memantine together with dextromethorphan may increase the risk of side effects of memantine or dextromethorphan such as dizziness, drowsiness, and/or confusion. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition.
It can be intentional, when combining drugs with similar actions adds demonstrated therapeutic benefit — or unintentional, such as when a patient sees multiple prescribers or fills prescriptions at more than one pharmacy, which can lead to adverse effects.
Duplication:
Nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'NMDA antagonists' category:
- Iophen DM NR (dextromethorphan/guaifenesin)
- memantine
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
dextromethorphan Food/Lifestyle
Applies to: Iophen DM NR (dextromethorphan / guaifenesin)
Alcohol can increase the nervous system side effects of dextromethorphan such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with dextromethorphan. Do not use more than the recommended dose of dextromethorphan, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
Disease interactions
3 potential interactions Applies to: 3 conditions, including Urinary Tract Infection, Liver Disease, and Renal Dysfunction.
Liver Disease
Moderate:
memantine
Memantine has a moderate potential interaction with Liver Disease.
Memantine should be used with caution in patients with severe hepatic impairment and a dosage reduction is recommended. No dosage adjustment is needed in patients with mild or moderate hepatic impairment.
Renal Dysfunction
Moderate:
memantine
Memantine has a moderate potential interaction with Renal Dysfunction.
Memantine renal clearance involves active tubular secretion moderated by pH dependent tubular reabsorption and conditions that raise urine pH may increase the plasma levels of memantine. Therapy with memantine should be used cautiously in patients with conditions that raise urine pH, such as renal tubular acidosis or severe infections of the urinary tract. Additionally, memantine should be used with caution in patients with severe renal impairment and a dosage reduction is recommended. No dosage adjustment is needed in patients with mild or moderate renal impairment.
Urinary Tract Infection
Moderate:
memantine
Memantine has a moderate potential interaction with Urinary Tract Infection.
Memantine renal clearance involves active tubular secretion moderated by pH dependent tubular reabsorption and conditions that raise urine pH may increase the plasma levels of memantine. Therapy with memantine should be used cautiously in patients with conditions that raise urine pH, such as renal tubular acidosis or severe infections of the urinary tract. Additionally, memantine should be used with caution in patients with severe renal impairment and a dosage reduction is recommended. No dosage adjustment is needed in patients with mild or moderate renal impairment.
Report options
More resources
Iophen DM NR
A total of 375 drugs are known to interact with Iophen DM NR.
- Iophen dm nr is in the drug class upper respiratory combinations.
- Iophen dm nr is used to treat the following conditions:
memantine
A total of 43 drugs are known to interact with memantine.
- Memantine is in the drug class miscellaneous central nervous system agents.
-
Memantine is used to treat the following conditions:
- Alzheimer's Disease
- Autism (off-label)
- Migraine (off-label)
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.