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Drug Interactions between Harvoni and ranitidine

This report displays the potential drug interactions for the following 2 drugs:

  • Harvoni (ledipasvir/sofosbuvir)
  • ranitidine

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Interactions between your drugs


raNITIdine ledipasvir

Applies to: ranitidine and Harvoni (ledipasvir / sofosbuvir)

Depending on the dose, raNITIdine may interfere with the absorption of ledipasvir and reduce its effectiveness. Talk to your doctor or pharmacist if you have any questions or concerns. You may need a dose adjustment of raNITIdine to safely use both medications. You should take raNITIdine simultaneously with or 12 hours apart from the dose of ledipasvir. Contact your doctor if your symptoms worsen or your condition changes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

No interactions were found. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.