Can you take Flibanserin with Troglitazone?

Flibanserin has a major potential interaction with Alcoholism.

The use of flibanserin is contraindicated along with the ingestion of alcohol, as it increases the risk of hypotension and syncope. It is important to assess the likelihood of the patient abstaining from alcohol, taking into account the current and past drinking behavior.

Troglitazone has a major potential interaction with Alcoholism.

The initiation of troglitazone therapy is contraindicated in patients who have a history of liver disease or alcohol abuse; exhibit clinical evidence of active liver disease; or demonstrate increased serum transaminase levels (ALT > 1.5 times the upper limit of normal). The use of troglitazone has been associated with significant elevations in serum ALT levels as well as severe idiosyncratic hepatocellular injury, which has generally been reversible but, in a few cases, led to liver transplant or death. Injury has occurred after both short- and long-term treatment. Patients who receive troglitazone therapy should have serum transaminase levels checked at the start of therapy, at least monthly for the first year, and at least quarterly thereafter. If signs or symptoms suggestive of liver injury occur, liver function tests should be performed. Moderate elevations (ALT > 1.5 to 2 times ULN) require immediate re-testing and weekly monitoring until levels return to normal. Troglitazone should be withdrawn if ALT rises above 3 times ULN or jaundice develops.

Troglitazone has a moderate potential interaction with Diabetes Mellitus.

New onset or worsening diabetic macular edema with decreased visual acuity have been reported in postmarketing reports in some diabetic patients who were taking thiazolidinedione drugs. Some patients presented with blurred vision or decreased visual acuity, but some patients appear to have been diagnosed on routine ophthalmologic examination. Most patients had peripheral edema at the time macular edema was diagnosed. Some patients had improvement in their macular edema after discontinuation of their thiazolidinedione. Patients with diabetes should have regular eye exams by an ophthalmologist according to current standards of care. Additionally, any diabetic who reports any kind of visual symptom should be promptly referred to an ophthalmologist, regardless of the patient's underlying medications or other physical findings.

Troglitazone has a moderate potential interaction with Diabetic Macular Edema.

New onset or worsening diabetic macular edema with decreased visual acuity have been reported in postmarketing reports in some diabetic patients who were taking thiazolidinedione drugs. Some patients presented with blurred vision or decreased visual acuity, but some patients appear to have been diagnosed on routine ophthalmologic examination. Most patients had peripheral edema at the time macular edema was diagnosed. Some patients had improvement in their macular edema after discontinuation of their thiazolidinedione. Patients with diabetes should have regular eye exams by an ophthalmologist according to current standards of care. Additionally, any diabetic who reports any kind of visual symptom should be promptly referred to an ophthalmologist, regardless of the patient's underlying medications or other physical findings.

Flibanserin has a major potential interaction with Hypotension.

The use of flibanserin can cause hypotension and syncope. The benefits and risks of therapy should be considered in patients with preexisting conditions that predispose to hypotension. Flibanserin should be used with caution in these patients.

Flibanserin has a major potential interaction with Liver Disease.

Flibanserin may accumulate in patients with hepatic impairment. Therapy with flibanserin is contraindicated in patients with compromised hepatic function.

Troglitazone has a major potential interaction with Liver Disease.

The initiation of troglitazone therapy is contraindicated in patients who have a history of liver disease or alcohol abuse; exhibit clinical evidence of active liver disease; or demonstrate increased serum transaminase levels (ALT > 1.5 times the upper limit of normal). The use of troglitazone has been associated with significant elevations in serum ALT levels as well as severe idiosyncratic hepatocellular injury, which has generally been reversible but, in a few cases, led to liver transplant or death. Injury has occurred after both short- and long-term treatment. Patients who receive troglitazone therapy should have serum transaminase levels checked at the start of therapy, at least monthly for the first year, and at least quarterly thereafter. If signs or symptoms suggestive of liver injury occur, liver function tests should be performed. Moderate elevations (ALT > 1.5 to 2 times ULN) require immediate re-testing and weekly monitoring until levels return to normal. Troglitazone should be withdrawn if ALT rises above 3 times ULN or jaundice develops.

Flibanserin has a major potential interaction with Syncope.

The use of flibanserin can cause hypotension and syncope. The benefits and risks of therapy should be considered in patients with preexisting conditions that predispose to hypotension. Flibanserin should be used with caution in these patients.