Can you take Flibanserin with Mitapivat?
1 drug interaction and 8 additional warnings found for the following 2 drugs:
- flibanserin
- mitapivat
Drug interactions
Moderate drug interactions
Moderate:
flibanserin mitapivat
Applies to: flibanserin and mitapivat
Mitapivat may reduce the blood levels and effects of flibanserin.
Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Major food/lifestyle interactions
Major:
flibanserin Food/Lifestyle
Applies to: flibanserin
Do not use alcohol too close to the dosing time of flibanserin. Doing so can cause excessive drowsiness and decreases in blood pressure, which may lead to:
- dizziness
- lightheadedness
- fainting
- accidental injury
What to do: Take flibanserin at bedtime to minimize the risk of these effects. It is recommended that you stop drinking alcohol at least two hours before taking flibanserin; otherwise, you should just skip the flibanserin dose that evening. Alcohol should not be consumed until at least the morning after taking flibanserin at bedtime.
Because grapefruit juice can significantly increase the blood levels of flibanserin, you should also avoid the consumption of grapefruit and grapefruit juice during treatment.
Talk to your healthcare provider if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Major:
mitapivat Food/Lifestyle
Applies to: mitapivat
Grapefruit juice can increase the blood levels of mitapivat.
This may increase side effects such as:
- joint pain
- increased uric acid blood levels
- back pain
- in men, decreased reproductive hormones
You should avoid consuming grapefruit and grapefruit juice during treatment with mitapivat.
However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication.
Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
6 potential interactions Applies to: 5 conditions, including Hypotension, Syncope, Liver Disease, Alcoholism, and Renal Dysfunction.
Alcoholism
Major:
flibanserin
Flibanserin has a major potential interaction with Alcoholism.
The use of flibanserin is contraindicated along with the ingestion of alcohol, as it increases the risk of hypotension and syncope. It is important to assess the likelihood of the patient abstaining from alcohol, taking into account the current and past drinking behavior.
Hypotension
Major:
flibanserin
Flibanserin has a major potential interaction with Hypotension.
The use of flibanserin can cause hypotension and syncope. The benefits and risks of therapy should be considered in patients with preexisting conditions that predispose to hypotension. Flibanserin should be used with caution in these patients.
Liver Disease
Major:
flibanserin
Flibanserin has a major potential interaction with Liver Disease.
Flibanserin may accumulate in patients with hepatic impairment. Therapy with flibanserin is contraindicated in patients with compromised hepatic function.
Moderate:
mitapivat
Mitapivat has a moderate potential interaction with Liver Disease.
Mitapivat undergoes extensive hepatic metabolism. The systemic exposure of mitapivat is expected to increase with moderate and severe liver dysfunction. Mitapivat should not be used in patients with moderate to severe liver dysfunction.
Renal Dysfunction
Moderate:
mitapivat
Mitapivat has a moderate potential interaction with Renal Dysfunction.
The effects of renal dysfunction on mitapivat pharmacokinetics were assessed with population pharmacokinetic analyses. There are limited data available in patients with estimated glomerular filtration rate (eGFR) 30 to less than 60 mL/min/1.73 m2 and no data available in patients with eGFR less than 30 mL/min/1.73 m2; caution is recommended in these patients.
Syncope
Major:
flibanserin
Flibanserin has a major potential interaction with Syncope.
The use of flibanserin can cause hypotension and syncope. The benefits and risks of therapy should be considered in patients with preexisting conditions that predispose to hypotension. Flibanserin should be used with caution in these patients.
Report options
More resources
flibanserin
A total of 517 drugs are known to interact with flibanserin.
- Flibanserin is in the drug class miscellaneous central nervous system agents.
- Flibanserin is used to treat Hypoactive Sexual Desire Disorder.
mitapivat
A total of 411 drugs are known to interact with mitapivat.
- Mitapivat is in the drug class miscellaneous metabolic agents.
- Mitapivat is used to treat the following conditions:
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.