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Drug Interactions between estradiol and Myzilra

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

No interactions were found between estradiol and Myzilra. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

estradiol

A total of 390 drugs are known to interact with estradiol.

Myzilra

A total of 496 drugs are known to interact with Myzilra.

Drug and food interactions

Moderate

levonorgestrel food

Applies to: Myzilra (ethinyl estradiol / levonorgestrel)

Grapefruit juice may increase the blood levels of certain medications such as levonorgestrel. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with levonorgestrel. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

Moderate

ethinyl estradiol food

Applies to: Myzilra (ethinyl estradiol / levonorgestrel)

Consumer information for this interaction is not currently available.

MONITOR: Coadministration of ethinyl estradiol may increase the plasma concentrations of drugs that are primarily metabolized by CYP450 1A2. In a study of 30 healthy volunteers administered the CYP450 1A2 substrate tizanidine, the systemic exposure (AUC) of tizanidine was 3.9 times greater in women using an oral contraceptive containing ethinyl estradiol.

MANAGEMENT: Patients should be monitored for increased adverse effects of the CYP450 1A2 substrate during concomitant use with ethinyl estradiol. Product labeling for the specific CYP450 1A2 substrate should be consulted for additional recommendations.

Minor

ethinyl estradiol food

Applies to: Myzilra (ethinyl estradiol / levonorgestrel)

Information for this minor interaction is available on the professional version.

Minor

estradiol food

Applies to: estradiol

Information for this minor interaction is available on the professional version.

Minor

ethinyl estradiol food

Applies to: Myzilra (ethinyl estradiol / levonorgestrel)

Information for this minor interaction is available on the professional version.

Minor

levonorgestrel food

Applies to: Myzilra (ethinyl estradiol / levonorgestrel)

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Estrogens

Therapeutic duplication

The recommended maximum number of medicines in the 'estrogens' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'estrogens' category:

  • estradiol
  • Myzilra (ethinyl estradiol/levonorgestrel)

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer