Drug Interactions between Entocort EC and mercaptopurine
This report displays the potential drug interactions for the following 2 drugs:
- Entocort EC (budesonide)
- mercaptopurine
Interactions between your drugs
No interactions were found between Entocort EC and mercaptopurine. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Entocort EC
A total of 511 drugs are known to interact with Entocort EC.
- Entocort ec is in the drug class glucocorticoids.
- Entocort ec is used to treat the following conditions:
mercaptopurine
A total of 280 drugs are known to interact with mercaptopurine.
- Mercaptopurine is in the drug class antimetabolites.
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Mercaptopurine is used to treat the following conditions:
- Acute Lymphoblastic Leukemia
- Autoimmune Hepatitis (off-label)
- Crohn's Disease, Active (off-label)
- Crohn's Disease, Maintenance (off-label)
- Inflammatory Bowel Disease (off-label)
- Intestinal Arterial Insufficiency (off-label)
- Ulcerative Colitis, Maintenance (off-label)
Drug and food interactions
mercaptopurine food
Applies to: mercaptopurine
ADJUST DOSING INTERVAL: Limited data suggest that food may decrease the oral bioavailability of 6-mercaptopurine (6-MP). In one study, the pharmacokinetics of 6-MP were studied on two separate occasions in seven patients. A single dose of 6-MP was administered after an overnight fast on one occasion and 15 minutes after a standard breakfast on the other. The authors reported that peak plasma levels of 6-MP were lower and took longer to reach following administration in the fed state. In addition, plasma levels were undetectable (less than 20 ng/mL) in two patients.
MANAGEMENT: Until more information is available regarding the effect of food on 6-MP absorption, it may be advisable to take 6-MP on an empty stomach 1 hour before or 2 hours after a meal.
References
- Schmidt LE, Dalhoff K (2002) "Food-drug interactions." Drugs, 62, p. 1481-502
budesonide food
Applies to: Entocort EC (budesonide)
GENERALLY AVOID: Grapefruit juice may increase the plasma concentrations and systemic effects of orally administered budesonide. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. According to the manufacturer, the systemic exposure of oral budesonide approximately doubles after extensive intake of grapefruit juice.
MANAGEMENT: Patients receiving budesonide should avoid the regular consumption of grapefruits and grapefruit juice to prevent undue increases in plasma budesonide levels and systemic effects.
References
- (2001) "Product Information. Entocort (budesonide)." AstraZeneca Pharma Inc
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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